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Peer-reviewedCC BY-NCIranian journal of parasitology

Exploring the Gut-Skin Microbiome and Leishmaniasis: A Systematic Review of Current Evidence.

  • Azadeh Zolfaghari1
  • Sarah Seyedyousefi1
  • Parisa Mousavi1
  • Zabihollah Shahmoradi1
  • Hanieh Sharifian1
  • Maryam Aghaei1
  • Seyed Mohsen Hosseini1
  1. 1Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
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Abstract

Background

This review investigated the impact of skin and gut microbiomes on the development of leishmaniasis. Dysbiosis in these microbiomes is associated with various skin disorders through mechanisms related to immune modulation and inflammation. Leishmaniasis primarily presents as cutaneous wounds. The immune response of the host to Leishmania plays a crucial role in determining the disease's severity and treatment effectiveness. Gaining insight into these microbiome-immune dynamics is essential for improving the prevention and management of leishmaniasis.Methods

A thorough analysis of the most recent research was done, emphasizing the functions of chemokines and cytokines in Leishmania infection. Synthesizing key findings from research indexed by PubMed, Scopus, Web of Science, Science Direct, EMBASE, and Magiran up to June 2024 provided an extensive understanding of immunological mechanisms. Eventually, 19 manuscripts were included in this review and thoroughly investigated and reported.Results

The delicate balance between pro- and anti-inflammatory signals in the immune response to Leishmania infection largely depends on the commensal microbial populations.Conclusion

Future research should concentrate on modifying these reactions to improve treatment outcomes for leishmaniasis.

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Cite

BibTeXRIS
BibTeX
@article{zolfaghari2026exploring,
  title = {{Exploring the Gut-Skin Microbiome and Leishmaniasis: A Systematic Review of Current Evidence.}},
  author = {Azadeh Zolfaghari and Sarah Seyedyousefi and Parisa Mousavi and Zabihollah Shahmoradi and Hanieh Sharifian and Maryam Aghaei and Seyed Mohsen Hosseini},
  journal = {Iranian journal of parasitology},
  year = {2026},
  month = jul,
  doi = {10.18502/ijpa.v21i3.22588},
  url = {https://europepmc.org/article/MED/42974165},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Exploring the Gut-Skin Microbiome and Leishmaniasis: A Systematic Review of Current Evidence.
AU  - Azadeh Zolfaghari
AU  - Sarah Seyedyousefi
AU  - Parisa Mousavi
AU  - Zabihollah Shahmoradi
AU  - Hanieh Sharifian
AU  - Maryam Aghaei
AU  - Seyed Mohsen Hosseini
PY  - 2026
DA  - 2026/07/01
JO  - Iranian journal of parasitology
DO  - 10.18502/ijpa.v21i3.22588
UR  - https://europepmc.org/article/MED/42974165
AB  - Background  This review investigated the impact of skin and gut microbiomes on the development of leishmaniasis. Dysbiosis in these microbiomes is associated with various skin disorders through mechanisms related to immune modulation and inflammation. Leishmaniasis primarily presents as cutaneous wounds. The immune response of the host to Leishmania plays a crucial role in determining the disease's severity and treatment effectiveness. Gaining insight into these microbiome-immune dynamics is essential for improving the prevention and management of leishmaniasis.Methods  A thorough analysis of the most recent research was done, emphasizing the functions of chemokines and cytokines in Leishmania infection. Synthesizing key findings from research indexed by PubMed, Scopus, Web of Science, Science Direct, EMBASE, and Magiran up to June 2024 provided an extensive understanding of immunological mechanisms. Eventually, 19 manuscripts were included in this review and thoroughly investigated and reported.Results  The delicate balance between pro- and anti-inflammatory signals in the immune response to Leishmania infection largely depends on the commensal microbial populations.Conclusion  Future research should concentrate on modifying these reactions to improve treatment outcomes for leishmaniasis.
SN  - 1735-7020
SN  - 2008-238X
ER  -