Electrochemical Skeletal Editing
- 1Georg-August-Universität Göttingen , , Tammannstraße 2 , ,
- 2Georg-August-Universität Göttingen , , Robert-Koch-Straße 40 , ,
Abstract
Skeletal editing has emerged as a transformative strategy for the direct remodeling of molecular frameworks through selective atom insertion, deletion, or exchange. Through structural remodeling at the molecular core, skeletal editing provides rapid access to diverse and valuable architectures while circumventing lengthy de novo or multistep synthetic routes. In recent years, the merger of skeletal editing and electrochemistry has unlocked entirely new opportunities for sustainable and programmable molecular editing. Thus, protons and electrons serve as traceless redox reagents, enabling distinct reaction manifolds compared with conventional thermal approaches. Moreover, electrochemical activation offers unique advantages, including tunable redox control, reduced chemical waste, and access to reactive intermediates under mild reaction conditions. In this perspective, we highlight recent advances in electrochemical skeletal editing until September 2026, with particular emphasis on electrochemical atom insertion, ring expansion, and ring contraction strategies.
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BibTeX
@article{hamad2026electrochemical,
title = {{Electrochemical Skeletal Editing}},
author = {Aboubakr Hamad and Tristan Bauch and Piotr Skumial and Lutz Ackermann},
journal = {JACS Au},
year = {2026},
month = nov,
doi = {10.1021/jacsau.6c01196},
url = {https://pubs.acs.org/jaaucr/article/doi/10.1021/jacsau.6c01196/5466059/Electrochemical-Skeletal-Editing},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Electrochemical Skeletal Editing
AU - Aboubakr Hamad
AU - Tristan Bauch
AU - Piotr Skumial
AU - Lutz Ackermann
PY - 2026
DA - 2026/11/06
JO - JACS Au
DO - 10.1021/jacsau.6c01196
UR - https://pubs.acs.org/jaaucr/article/doi/10.1021/jacsau.6c01196/5466059/Electrochemical-Skeletal-Editing
AB - Skeletal editing has emerged as a transformative strategy for the direct remodeling of molecular frameworks through selective atom insertion, deletion, or exchange. Through structural remodeling at the molecular core, skeletal editing provides rapid access to diverse and valuable architectures while circumventing lengthy de novo or multistep synthetic routes. In recent years, the merger of skeletal editing and electrochemistry has unlocked entirely new opportunities for sustainable and programmable molecular editing. Thus, protons and electrons serve as traceless redox reagents, enabling distinct reaction manifolds compared with conventional thermal approaches. Moreover, electrochemical activation offers unique advantages, including tunable redox control, reduced chemical waste, and access to reactive intermediates under mild reaction conditions. In this perspective, we highlight recent advances in electrochemical skeletal editing until September 2026, with particular emphasis on electrochemical atom insertion, ring expansion, and ring contraction strategies.
SN - 2691-3704
ER -