Skip to content
DraconiticResearch
Search Sources API
203,948 studies31 sourcesUpdated 6 min ago
Peer-reviewedCC BYJournal of Functional Foods

Dietary chlorogenic acid and digestive health: sources, bioavailability, antioxidant mechanisms and intervention potential

  • Yihong Wang1
  • Xiaoyu Huang1
  • Sen Wang1
  • Rongjie Li1
  • Letian Zhang2
  • Xinyu Yu2
  • Yifei Liu2
  • Ni Zhu3
  • Yanhong Zhou3
  1. 1School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, China
  2. 2School of Stomatology and Ophthalmology, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, China
  3. 3School of Stomatology and Ophthalmology, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, China; Corresponding author at: School of Stomatology and Ophthalmology, Xianning Medical College, Hubei University of Science and Technology, 88 Xianning Avenue, Xianning 437100, Hubei Province, PR China
Read full textPDFDOICite

Abstract

Chlorogenic acid (CGA) is a dietary phenolic compound that is widely distributed in plant-based foods and is recognized for its antioxidant and anti-inflammatory activities. This review summarizes the dietary sources, processing stability, bioavailability, metabolism, and health-related effects of CGA, focusing on oxidative stress and digestive health. CGA and related chlorogenic acids are widely distributed in coffee, tea, fruits, vegetables, and medicinal food homologous plants, but its stability is influenced by temperature, light, and pH. After ingestion, the bioavailability of CGA is limited, and it is extensively metabolized to generate bioactive derivatives. Its health-related effects are associated with reactive oxygen species regulation, Nrf2/ARE activation, inflammatory signaling, and cellular homeostasis. The current evidence suggests that CGA may support digestive health. However, its low bioavailability and limited clinical evidence remain challenges. Future studies should focus on delivery strategies and intervention in humans.

Related

  1. Dietary chlorogenic acid improves sperm kinematics in aging breeder roosters via modulation of the Nrf2-mediated antioxidant pathway
    Xiangsen Zeng, Boxuan Fu, Xihui Sheng +4
    Poultry SciencePeer-reviewedCC BY-NC-ND 4.0Full textObstetrics, gynaecology & paediatricsPMCEurope PMC
  2. Potential Mechanisms of Chlorogenic Acid in Cognitive Impairment: A Comprehensive Review
    Yuxuan Liu, Shijun Wang
    MoleculesPeer-reviewedCC BY 4.0General medicineCrossref
  3. Centaurea pungens Pomel as a potential nutraceutical source: Polyphenol-rich profile, antioxidant capacity, and inhibition of digestive α-amylase
    Randa Mlik, Mohamed Amine Fares, Nour Elhouda Mekhadmi +13
    Frontiers in NutritionPeer-reviewedCC BY 4.0Full textEndocrinology & metabolismHAL
  4. Optimization of ultrasound-assisted extraction of polyphenols from Mansoa alliacea flowers and evaluation of their antioxidant, anti-inflammatory-related, and digestive enzyme inhibitory activities.
    Quoc Trung Nguyen, Tran Chi Linh
    Biochemistry and biophysics reportsPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Curcumin and Boswellia in Inflammatory Disorders: Immune Mechanisms, Bioavailability and Dose Comparability
    Sigrun Chrubasik-Hausmann, Julia Vlachojannis
    NutrientsPeer-reviewedCC BY 4.0NutritionCrossref

Cite

BibTeXRIS
BibTeX
@article{wang2026dietary,
  title = {{Dietary chlorogenic acid and digestive health: sources, bioavailability, antioxidant mechanisms and intervention potential}},
  author = {Yihong Wang and Xiaoyu Huang and Sen Wang and Rongjie Li and Letian Zhang and Xinyu Yu and Yifei Liu and Ni Zhu and Yanhong Zhou},
  journal = {Journal of Functional Foods},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jff.2026.107564},
  url = {https://doi.org/10.1016/j.jff.2026.107564},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Dietary chlorogenic acid and digestive health: sources, bioavailability, antioxidant mechanisms and intervention potential
AU  - Yihong Wang
AU  - Xiaoyu Huang
AU  - Sen Wang
AU  - Rongjie Li
AU  - Letian Zhang
AU  - Xinyu Yu
AU  - Yifei Liu
AU  - Ni Zhu
AU  - Yanhong Zhou
PY  - 2026
DA  - 2026/10/30
JO  - Journal of Functional Foods
DO  - 10.1016/j.jff.2026.107564
UR  - https://doi.org/10.1016/j.jff.2026.107564
AB  - Chlorogenic acid (CGA) is a dietary phenolic compound that is widely distributed in plant-based foods and is recognized for its antioxidant and anti-inflammatory activities. This review summarizes the dietary sources, processing stability, bioavailability, metabolism, and health-related effects of CGA, focusing on oxidative stress and digestive health. CGA and related chlorogenic acids are widely distributed in coffee, tea, fruits, vegetables, and medicinal food homologous plants, but its stability is influenced by temperature, light, and pH. After ingestion, the bioavailability of CGA is limited, and it is extensively metabolized to generate bioactive derivatives. Its health-related effects are associated with reactive oxygen species regulation, Nrf2/ARE activation, inflammatory signaling, and cellular homeostasis. The current evidence suggests that CGA may support digestive health. However, its low bioavailability and limited clinical evidence remain challenges. Future studies should focus on delivery strategies and intervention in humans.
SN  - 1756-4646
SN  - 2214-9414
ER  -