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Peer-reviewedCC BY-NC-NDJournal of medical case reports

S. carcinoma arising in a breast implant: a case report and review of the literature.

  • Gustavo Adolfo Villegas-Gomez1
  • Valentina Pérez-Ariza2
  • Marcela Mejía-Arango2,3
  • María Isabel Rizo4
4 affiliations
  1. 1School of Medicine, Universidad de los Andes, Bogotá, Colombia. [email protected].
  2. 2School of Medicine, Universidad de los Andes, Bogotá, Colombia.
  3. 3Department of Pathology and Laboratory Medicine, Fundación Santa Fe de Bogotá, Bogotá, Colombia.
  4. 4Department of Surgery, Fundación Santa Fe de Bogotá, Bogotá, Colombia. [email protected].
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Abstract

Background

Breast implants are widely used in plastic surgery and generally considered safe. However, recent reports of implant-associated malignancies, including anaplastic large-cell lymphoma and squamous-cell carcinoma, have raised concern. This report presents a case of squamous-cell carcinoma arising in a silicone breast implant and reviews the current literature on its association with breast implants.Case presentation

A 48-year-old Hispanic female presented with pain and asymmetry of the left breast. Persistent symptoms and imaging findings led to the identification of a cystic mass associated with a silicone implant. Histopathological analysis confirmed squamous-cell carcinoma arising from the periprosthetic capsule. The patient underwent implant removal, and after radiologic surveillance and diagnosis of recurrence, an attempted oncoplastic approach was converted intraoperatively to a radical mastectomy due to extensive tumor infiltration. No adjuvant therapy was administered. At 12-month follow-up, the patient remains disease-free without evidence of recurrence.Conclusions

The diagnosis and management of breast-implant-associated squamous-cell carcinoma require a multidisciplinary approach due to its unpredictable behavior. Increased awareness, early detection, and individualized treatment strategies are essential to improve outcomes in this rare but aggressive entity.

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Cite

BibTeXRIS
BibTeX
@article{villegasgomez2026carcinoma,
  title = {{S. carcinoma arising in a breast implant: a case report and review of the literature.}},
  author = {Gustavo Adolfo Villegas-Gomez and Valentina Pérez-Ariza and Marcela Mejía-Arango and María Isabel Rizo},
  journal = {Journal of medical case reports},
  year = {2026},
  month = jul,
  doi = {10.1186/s13256-026-05867-6},
  url = {https://europepmc.org/article/MED/42902393},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - S. carcinoma arising in a breast implant: a case report and review of the literature.
AU  - Gustavo Adolfo Villegas-Gomez
AU  - Valentina Pérez-Ariza
AU  - Marcela Mejía-Arango
AU  - María Isabel Rizo
PY  - 2026
DA  - 2026/07/01
JO  - Journal of medical case reports
DO  - 10.1186/s13256-026-05867-6
UR  - https://europepmc.org/article/MED/42902393
AB  - Background  Breast implants are widely used in plastic surgery and generally considered safe. However, recent reports of implant-associated malignancies, including anaplastic large-cell lymphoma and squamous-cell carcinoma, have raised concern. This report presents a case of squamous-cell carcinoma arising in a silicone breast implant and reviews the current literature on its association with breast implants.Case presentation  A 48-year-old Hispanic female presented with pain and asymmetry of the left breast. Persistent symptoms and imaging findings led to the identification of a cystic mass associated with a silicone implant. Histopathological analysis confirmed squamous-cell carcinoma arising from the periprosthetic capsule. The patient underwent implant removal, and after radiologic surveillance and diagnosis of recurrence, an attempted oncoplastic approach was converted intraoperatively to a radical mastectomy due to extensive tumor infiltration. No adjuvant therapy was administered. At 12-month follow-up, the patient remains disease-free without evidence of recurrence.Conclusions  The diagnosis and management of breast-implant-associated squamous-cell carcinoma require a multidisciplinary approach due to its unpredictable behavior. Increased awareness, early detection, and individualized treatment strategies are essential to improve outcomes in this rare but aggressive entity.
SN  - 1752-1947
ER  -