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Peer-reviewedCC BYCase reports in surgery

Ductal Carcinoma In Situ With Microinvasion Arising in a Breast Hamartoma: A Case Report and Review of Guidelines of Hamartoma Management.

  • Buket Ertansel1
  • Geetha Joseph2
  • Oniaza Syed3
  • Anna Kirby4
  • Marina Parton5
  • Sarah Shuk-Kay Tang1
5 affiliations
  1. 1Department of Breast Surgery St. George's Hospital NHS Foundation Trust Blackshaw Road SW17 0QT London UK nhs.uk.
  2. 2Department of Histopathology Kingston Hospital Kingston and Richmond NHS Foundation Trust Kingston Upon Thames KT2 7QB, Galsworthy Rd London UK kingstonhospital.nhs.uk.
  3. 3Department of Clinical Radiology Kingston Hospital Kingston and Richmond NHS Foundation Trust Galsworthy Rd, Kingston Upon Thames KT2 7QB London UK kingstonhospital.nhs.uk.
  4. 4Royal Marsden Institute of Cancer Research London UK icr.ac.uk.
  5. 5Kingston Hospital Kingston and Richmond NHS Foundation Trust Galsworthy Rd, Kingston Upon Thames KT2 7QB London UK kingstonhospital.nhs.uk.
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Abstract

Breast hamartomas are rare, benign lesions composed of adipose, fibrous and glandular tissue. While typically non-malignant and not linked to increased breast cancer risk, they are often underdiagnosed due to variable imaging and histological features. We report a rare case of ductal carcinoma in situ (DCIS) with microinvasion arising within a mammary hamartoma. Unexpectedly the patient went on to develop a triple-negative invasive breast cancer 6 months following nipple-sparing mastectomy and implant reconstruction. To date, only 16 cases of breast carcinoma within hamartomas have been reported, making this case an important addition to the limited literature. It highlights the need for careful imaging interpretation, pathological review and multidisciplinary management, particularly in lesions with glandular components or atypical features. With increasing use of breast imaging, identification of hamartomas is expected to rise, making awareness of their rare malignant potential essential. In the absence of prevalence data or management guidelines, this case underscores the value of centralised reporting and collaborative clinical decision-making.

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Cite

BibTeXRIS
BibTeX
@article{ertansel2026ductal,
  title = {{Ductal Carcinoma In Situ With Microinvasion Arising in a Breast Hamartoma: A Case Report and Review of Guidelines of Hamartoma Management.}},
  author = {Buket Ertansel and Geetha Joseph and Oniaza Syed and Anna Kirby and Marina Parton and Sarah Shuk-Kay Tang},
  journal = {Case reports in surgery},
  year = {2026},
  month = oct,
  doi = {10.1155/cris/1681410},
  url = {https://europepmc.org/article/MED/42948616},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Ductal Carcinoma In Situ With Microinvasion Arising in a Breast Hamartoma: A Case Report and Review of Guidelines of Hamartoma Management.
AU  - Buket Ertansel
AU  - Geetha Joseph
AU  - Oniaza Syed
AU  - Anna Kirby
AU  - Marina Parton
AU  - Sarah Shuk-Kay Tang
PY  - 2026
DA  - 2026/10/27
JO  - Case reports in surgery
DO  - 10.1155/cris/1681410
UR  - https://europepmc.org/article/MED/42948616
AB  - Breast hamartomas are rare, benign lesions composed of adipose, fibrous and glandular tissue. While typically non-malignant and not linked to increased breast cancer risk, they are often underdiagnosed due to variable imaging and histological features. We report a rare case of ductal carcinoma in situ (DCIS) with microinvasion arising within a mammary hamartoma. Unexpectedly the patient went on to develop a triple-negative invasive breast cancer 6 months following nipple-sparing mastectomy and implant reconstruction. To date, only 16 cases of breast carcinoma within hamartomas have been reported, making this case an important addition to the limited literature. It highlights the need for careful imaging interpretation, pathological review and multidisciplinary management, particularly in lesions with glandular components or atypical features. With increasing use of breast imaging, identification of hamartomas is expected to rise, making awareness of their rare malignant potential essential. In the absence of prevalence data or management guidelines, this case underscores the value of centralised reporting and collaborative clinical decision-making.
SN  - 2090-6900
SN  - 2090-6919
ER  -