Beyond DNA Damage: The Impact of Tobacco Smoke and Its Derivatives on MicroRNAs in Lung Cancer Pathogenesis
- 1Institute for the Medicine and Medical Technology, Novosibirsk State University, Pirogova Street, 1, Novosibirsk 630090, Russia
- 2Federal Research Center of Fundamental and Translational Medicine, Timakova Street, 2/12, Novosibirsk 630117, Russia
Abstract
Tobacco smoking continues to represent the leading risk factor for multiple malignancies, most notably lung cancer (LC), which exhibits a complex molecular pathogenesis. While classical models prioritize direct DNA damage and mutagenesis, growing evidence points to the role of mechanisms not directly dependent on structural DNA lesions. In particular, dysregulation of oncogenic and tumor-suppressive microRNAs (miRNAs) has emerged as a promising area of research. Although numerous miRNAs potentially involved in LC pathogenesis have been reported to be altered by tobacco exposure, the available evidence is fragmented. This heterogeneity, compounded by the chemical complexity of tobacco smoke, prevents the formation of a comprehensive landscape of its pathogenetic mechanisms. This review aims to systematize existing data on tobacco smoke–induced changes in miRNA expression profiles in LC, with reference to individual tobacco smoke constituents, and to identify key biological processes likely modulated by these changes.
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BibTeX
@article{perevalova2026beyond,
title = {{Beyond DNA Damage: The Impact of Tobacco Smoke and Its Derivatives on MicroRNAs in Lung Cancer Pathogenesis}},
author = {Alina M. Perevalova and Lyudmila F. Gulyaeva and Vladimir O. Pustylnyak},
journal = {Cancers},
year = {2026},
month = nov,
doi = {10.3390/cancers18213516},
url = {https://www.mdpi.com/2072-6694/18/21/3516},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Beyond DNA Damage: The Impact of Tobacco Smoke and Its Derivatives on MicroRNAs in Lung Cancer Pathogenesis
AU - Alina M. Perevalova
AU - Lyudmila F. Gulyaeva
AU - Vladimir O. Pustylnyak
PY - 2026
DA - 2026/11/01
JO - Cancers
DO - 10.3390/cancers18213516
UR - https://www.mdpi.com/2072-6694/18/21/3516
AB - Tobacco smoking continues to represent the leading risk factor for multiple malignancies, most notably lung cancer (LC), which exhibits a complex molecular pathogenesis. While classical models prioritize direct DNA damage and mutagenesis, growing evidence points to the role of mechanisms not directly dependent on structural DNA lesions. In particular, dysregulation of oncogenic and tumor-suppressive microRNAs (miRNAs) has emerged as a promising area of research. Although numerous miRNAs potentially involved in LC pathogenesis have been reported to be altered by tobacco exposure, the available evidence is fragmented. This heterogeneity, compounded by the chemical complexity of tobacco smoke, prevents the formation of a comprehensive landscape of its pathogenetic mechanisms. This review aims to systematize existing data on tobacco smoke–induced changes in miRNA expression profiles in LC, with reference to individual tobacco smoke constituents, and to identify key biological processes likely modulated by these changes.
SN - 2072-6694
ER -