Peer-reviewedCC BY-NC-NDJournal of Allergy and Clinical Immunology
Molecular engineering of a therapeutic antibody for Blo t 5–induced allergic asthma
Abstract
Epidemiological studies have established a causal link between sensitization to house dust mite (HDM) allergens and the development of allergic asthma. Despite the coexistence of the 2 major dust mite species in the tropics and dual sensitization profiles in atopic individuals, IgE responses targeting Blomia tropicalis have limited cross-reactivity with Dermatophagoides pteronyssinus.1 Among all known allergens of B tropicalis, Blo t 5 is the principal sensitizing allergen in tropical countries.
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BibTeX
@article{chan2026molecular,
title = {{Molecular engineering of a therapeutic antibody for Blo t 5–induced allergic asthma}},
author = {J.H. Sherlynn Chan and Yen Leong Chua and Hong Yong Peh and Vojislav Jovanovic and Nicholas R.J. Gascoigne and W. Wong and Fook Tim Chew and Brendon Hanson and David Kemeny and Paul Macary},
journal = {Journal of Allergy and Clinical Immunology},
year = {2026},
month = oct,
doi = {10.1016/j.jaci.2016.10.028},
url = {https://hal.science/hal-05787795v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Molecular engineering of a therapeutic antibody for Blo t 5–induced allergic asthma
AU - J.H. Sherlynn Chan
AU - Yen Leong Chua
AU - Hong Yong Peh
AU - Vojislav Jovanovic
AU - Nicholas R.J. Gascoigne
AU - W. Wong
AU - Fook Tim Chew
AU - Brendon Hanson
AU - David Kemeny
AU - Paul Macary
PY - 2026
DA - 2026/10/09
JO - Journal of Allergy and Clinical Immunology
DO - 10.1016/j.jaci.2016.10.028
UR - https://hal.science/hal-05787795v1
AB - Epidemiological studies have established a causal link between sensitization to house dust mite (HDM) allergens and the development of allergic asthma. Despite the coexistence of the 2 major dust mite species in the tropics and dual sensitization profiles in atopic individuals, IgE responses targeting Blomia tropicalis have limited cross-reactivity with Dermatophagoides pteronyssinus.1 Among all known allergens of B tropicalis, Blo t 5 is the principal sensitizing allergen in tropical countries.
SN - 0091-6749
ER -