Recent advances in synthesis of nitrogen-centered chiral compounds
- 1Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, School of Chemistry and Chemical Engineering, Huaibei Normal University Huaibei Anhui 235000 P. R. China
Abstract
Nitrogen-centered chiral compounds are widely found in natural products and pharmaceuticals, and can serve as multifunctional chiral catalysts, reagents, and ligands in asymmetric synthesis. However, the creation of nitrogen stereocenters remains a significant challenge. This difficulty arises from the low energy barrier for pyramidal inversion of the amine lone pair, which leads to rapid racemization. In recent years, breakthroughs in areas such as dynamic kinetic resolution, chiral ligand control, enzymatic catalysis, and organocatalysis have dramatically enhanced the efficiency of accessing configurationally stable nitrogen-centered chiral compounds. Herein, we present a detailed overview of the research progress in this field over the past five years, organized by the coordination number of the nitrogen stereocenter.
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BibTeX
@article{wang2026recent,
title = {{Recent advances in synthesis of nitrogen-centered chiral compounds}},
author = {Zi-Han Wang and Wangqin Ji and Tao-Yan Lin},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra07158a},
url = {https://europepmc.org/article/PMC/PMC13673145},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Recent advances in synthesis of nitrogen-centered chiral compounds
AU - Zi-Han Wang
AU - Wangqin Ji
AU - Tao-Yan Lin
PY - 2026
DA - 2026/10/16
JO - RSC advances
DO - 10.1039/d6ra07158a
UR - https://europepmc.org/article/PMC/PMC13673145
AB - Nitrogen-centered chiral compounds are widely found in natural products and pharmaceuticals, and can serve as multifunctional chiral catalysts, reagents, and ligands in asymmetric synthesis. However, the creation of nitrogen stereocenters remains a significant challenge. This difficulty arises from the low energy barrier for pyramidal inversion of the amine lone pair, which leads to rapid racemization. In recent years, breakthroughs in areas such as dynamic kinetic resolution, chiral ligand control, enzymatic catalysis, and organocatalysis have dramatically enhanced the efficiency of accessing configurationally stable nitrogen-centered chiral compounds. Herein, we present a detailed overview of the research progress in this field over the past five years, organized by the coordination number of the nitrogen stereocenter.
SN - 2046-2069
ER -