Dual Primary Malignancies in Breast Cancer: Clinical Characteristics and Survival Predictors Among Hakka Women in Meizhou
- 1Department of Breast Oncology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, Guangdong, People’s Republic of China
Abstract
Background: Breast cancer patients with dual primary malignancies (DPMs) exhibit distinct clinical features and survival outcomes. Although several relevant studies have been published, clinical evidence focusing on Hakka women is scarce. This study aimed to identify prognostic factors for overall survival (OS) among these patients.
Methods: This single-center retrospective study included Hakka women with breast cancer-associated DPMs in Meizhou. Patients were divided into synchronous and metachronous groups based on a 6-month diagnostic interval. We analyzed clinical features of breast cancer and other primary malignancies, including tumor sites of the latter, as well as their intergroup differences. OS was evaluated using the Kaplan–Meier method and Log rank test. Univariable and multivariable Cox regression analyses identified independent prognostic factors.
Results: A total of 155 patients were included, including 51 synchronous and 104 metachronous cases. Significant intergroup differences were observed in age, surgery and chemotherapy for breast cancer (all P < 0.05). Other primary malignancies were mainly located in the gynecological system, thyroid gland and lung. Multivariable analysis identified that longer interval time (HR 0.07, 95% CI 0.02–0.22; P < 0.001) was associated with better survival, whereas advanced breast cancer TNM stage (HR 2.49, 95% CI 1.11–5.60; P = 0.027) and advanced disease extent of other primary malignancies (HR 6.63, 95% CI 2.65–16.58; P < 0.001) were associated with worse survival.
Conclusion: The prognosis of Hakka women with breast cancer-associated DPMs is collectively influenced by interval time, breast cancer TNM stage, and disease extent of other primary malignancies. These findings provide real-world data for this patient group and highlight the importance of evaluating both primary malignancies in prognostic assessment. Given the retrospective single-center design and limited death events, these findings should be interpreted with caution.
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BibTeX
@article{wu2026dual,
title = {{Dual Primary Malignancies in Breast Cancer: Clinical Characteristics and Survival Predictors Among Hakka Women in Meizhou}},
author = {Jingna Wu and Yunuo Zhang and Qiuming Wang and Jinfeng Zhang and Bo Gao and Yan Chen},
journal = {Breast Cancer : Targets and Therapy},
year = {2026},
month = nov,
doi = {10.2147/bctt.s645434},
url = {https://doi.org/10.2147/bctt.s645434},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Dual Primary Malignancies in Breast Cancer: Clinical Characteristics and Survival Predictors Among Hakka Women in Meizhou
AU - Jingna Wu
AU - Yunuo Zhang
AU - Qiuming Wang
AU - Jinfeng Zhang
AU - Bo Gao
AU - Yan Chen
PY - 2026
DA - 2026/11/05
JO - Breast Cancer : Targets and Therapy
DO - 10.2147/bctt.s645434
UR - https://doi.org/10.2147/bctt.s645434
AB - Background: Breast cancer patients with dual primary malignancies (DPMs) exhibit distinct clinical features and survival outcomes. Although several relevant studies have been published, clinical evidence focusing on Hakka women is scarce. This study aimed to identify prognostic factors for overall survival (OS) among these patients. Methods: This single-center retrospective study included Hakka women with breast cancer-associated DPMs in Meizhou. Patients were divided into synchronous and metachronous groups based on a 6-month diagnostic interval. We analyzed clinical features of breast cancer and other primary malignancies, including tumor sites of the latter, as well as their intergroup differences. OS was evaluated using the Kaplan–Meier method and Log rank test. Univariable and multivariable Cox regression analyses identified independent prognostic factors. Results: A total of 155 patients were included, including 51 synchronous and 104 metachronous cases. Significant intergroup differences were observed in age, surgery and chemotherapy for breast cancer (all P < 0.05). Other primary malignancies were mainly located in the gynecological system, thyroid gland and lung. Multivariable analysis identified that longer interval time (HR 0.07, 95% CI 0.02–0.22; P < 0.001) was associated with better survival, whereas advanced breast cancer TNM stage (HR 2.49, 95% CI 1.11–5.60; P = 0.027) and advanced disease extent of other primary malignancies (HR 6.63, 95% CI 2.65–16.58; P < 0.001) were associated with worse survival. Conclusion: The prognosis of Hakka women with breast cancer-associated DPMs is collectively influenced by interval time, breast cancer TNM stage, and disease extent of other primary malignancies. These findings provide real-world data for this patient group and highlight the importance of evaluating both primary malignancies in prognostic assessment. Given the retrospective single-center design and limited death events, these findings should be interpreted with caution.
SN - 1179-1314
ER -