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Peer-reviewedCC BYOpen forum infectious diseases

Clinical Characteristics and Mortality Predictors of Group B Streptococcus Bacteremia in Adults: A Multicenter Retrospective Cohort Study in Japan, 2015-2024.

  • Kohei Oguni1,2
  • Hidemasa Akazawa1,2
  • Shinnosuke Fukushima1,3
  • Yasuhiro Suzuki4
  • Katsuki Kanai5
  • Yuto Haruki6
  • Kengo Mukuda7
  • Hidemaru Matsumoto8
  • Tatsuya Fujihara9,10
  • Hideharu Hagiya1
10 affiliations
  1. 1Department of Infectious Diseases, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  2. 2Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  3. 3Department of Bacteriology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  4. 4Emergency and Critical Care Center, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
  5. 5Department of Emergency and Critical Care Medicine, Shimane Prefectural Central Hospital, Izumo, Shimane, Japan.
  6. 6Department of Pharmacy, Tsuyama Chuo Hospital, Tsuyama, Okayama, Japan.
  7. 7Department of Infectious Diseases and General Internal Medicine, Tottori Prefectural Central Hospital, Tottori, Japan.
  8. 8Department of Pharmacy, Japanese Red Cross Society Himeji Hospital, Himeji, Hyogo, Japan.
  9. 9Department of General Internal Medicine, Masuda Red-Cross Hospital, Masuda, Shimane, Japan.
  10. 10Department of General Medicine, Okuizumo Hospital, Okuizumo, Shimane, Japan.
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Abstract

Background

Invasive group B Streptococcus (GBS) infection in nonpregnant adults is increasing, particularly among older adults and those with underlying comorbidities. However, multicenter data on prognostic factors for adult GBS bacteremia in Japan remain limited.Methods

We conducted a multicenter retrospective observational cohort study of adults with GBS bacteremia at 7 hospitals in western Japan between 2015 and 2024. Variables analyzed included clinical characteristics, infection sites, microbiological characteristics, and antimicrobial susceptibility profiles. Univariable and multivariable logistic regression analyses were performed to identify factors associated with 30-day mortality.Results

A total of 442 patients were included. Median age [interquartile range] was 75 [64-84] years, and 83.0% had at least 1 comorbidity. The overall 30-day all-cause mortality for GBS bacteremia was 9.3% (41/442), which rose to 39.3% (11/28) among patients with streptococcal toxic shock syndrome (STSS). In multivariable analysis, STSS was the strongest predictor of death (adjusted odds ratio [aOR], 9.16; 95% confidence interval [CI], 3.28-25.58), followed by immunosuppressive therapy (aOR, 4.62; 95% CI, 1.66-12.86), cirrhosis (aOR, 3.40; 95% CI, 1.23-9.40), respiratory infection (aOR, 3.30; 95% CI, 1.08-10.06), advanced renal dysfunction (aOR, 2.66; 95% CI, 1.09-6.52), and polymicrobial bacteremia (aOR, 2.40; 95% CI, 1.03-5.57), whereas skin and soft tissue infection was associated with lower mortality (aOR, 0.07; 95% CI, 0.01-0.53).Conclusions

Adult GBS bacteremia carries a high burden of short-term mortality, with a wide variety of clinical presentations, necessitating prompt diagnostic and therapeutic intervention.

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Cite

BibTeXRIS
BibTeX
@article{oguni2026clinical,
  title = {{Clinical Characteristics and Mortality Predictors of Group B Streptococcus Bacteremia in Adults: A Multicenter Retrospective Cohort Study in Japan, 2015-2024.}},
  author = {Kohei Oguni and Hidemasa Akazawa and Shinnosuke Fukushima and Yasuhiro Suzuki and Katsuki Kanai and Yuto Haruki and Kengo Mukuda and Hidemaru Matsumoto and Tatsuya Fujihara and Hideharu Hagiya},
  journal = {Open forum infectious diseases},
  year = {2026},
  month = oct,
  doi = {10.1093/ofid/ofag665},
  url = {https://europepmc.org/article/MED/42909912},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Clinical Characteristics and Mortality Predictors of Group B Streptococcus Bacteremia in Adults: A Multicenter Retrospective Cohort Study in Japan, 2015-2024.
AU  - Kohei Oguni
AU  - Hidemasa Akazawa
AU  - Shinnosuke Fukushima
AU  - Yasuhiro Suzuki
AU  - Katsuki Kanai
AU  - Yuto Haruki
AU  - Kengo Mukuda
AU  - Hidemaru Matsumoto
AU  - Tatsuya Fujihara
AU  - Hideharu Hagiya
PY  - 2026
DA  - 2026/10/09
JO  - Open forum infectious diseases
DO  - 10.1093/ofid/ofag665
UR  - https://europepmc.org/article/MED/42909912
AB  - Background  Invasive group B Streptococcus (GBS) infection in nonpregnant adults is increasing, particularly among older adults and those with underlying comorbidities. However, multicenter data on prognostic factors for adult GBS bacteremia in Japan remain limited.Methods  We conducted a multicenter retrospective observational cohort study of adults with GBS bacteremia at 7 hospitals in western Japan between 2015 and 2024. Variables analyzed included clinical characteristics, infection sites, microbiological characteristics, and antimicrobial susceptibility profiles. Univariable and multivariable logistic regression analyses were performed to identify factors associated with 30-day mortality.Results  A total of 442 patients were included. Median age [interquartile range] was 75 [64-84] years, and 83.0% had at least 1 comorbidity. The overall 30-day all-cause mortality for GBS bacteremia was 9.3% (41/442), which rose to 39.3% (11/28) among patients with streptococcal toxic shock syndrome (STSS). In multivariable analysis, STSS was the strongest predictor of death (adjusted odds ratio [aOR], 9.16; 95% confidence interval [CI], 3.28-25.58), followed by immunosuppressive therapy (aOR, 4.62; 95% CI, 1.66-12.86), cirrhosis (aOR, 3.40; 95% CI, 1.23-9.40), respiratory infection (aOR, 3.30; 95% CI, 1.08-10.06), advanced renal dysfunction (aOR, 2.66; 95% CI, 1.09-6.52), and polymicrobial bacteremia (aOR, 2.40; 95% CI, 1.03-5.57), whereas skin and soft tissue infection was associated with lower mortality (aOR, 0.07; 95% CI, 0.01-0.53).Conclusions  Adult GBS bacteremia carries a high burden of short-term mortality, with a wide variety of clinical presentations, necessitating prompt diagnostic and therapeutic intervention.
SN  - 2328-8957
ER  -