Diffuse Alveolar Haemorrhage Masquerading as Worsening ARDS in a Young Polytrauma Patient: Diagnostic Reasoning and a Conservative Management Bundle - A Case Report.
- 1Department of Emergency Intensive Care Unit, 920th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force, Kunming, Yunnan, People's Republic of China.
- 2Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, People's Republic of China.
Abstract
Background
Diffuse alveolar haemorrhage (DAH) is a rare, under-recognised complication of blunt polytrauma. In patients with severe acute respiratory distress syndrome (ARDS), new airway bleeding may be mistaken for pulmonary contusion, ventilator-associated pneumonia or transfusion-related acute lung injury (TRALI), delaying appropriate treatment. The timing of definitive fracture fixation also remains uncertain.Case presentation
A previously healthy man in his mid-20s sustained blunt polytrauma (Injury Severity Score 29; Glasgow Coma Scale 8), including multiple open comminuted fractures, a T11 compression fracture and bilateral pulmonary contusions. After emergency external fixation, he was transferred in haemorrhagic shock and respiratory failure, with severe ARDS (PaO₂/FiO₂ 78 mmHg), lactate 7.0 mmol/L and creatine kinase 4443 U/L. On day 4, he developed bloody endotracheal secretions, recurrent hypoxaemia, and abrupt decreases in haemoglobin (114 to 76 g/L) and platelets (139 to 65 × 10⁹/L). Bronchoscopy showed diffuse, non-focal mucosal oozing. Vasculitis and cytokine panels were negative. Targeted next-generation sequencing of bronchoalveolar lavage fluid detected high burdens of Acinetobacter baumannii and Klebsiella pneumoniae, low-abundance Pseudomonas aeruginosa, and multiple carbapenemase and extended-spectrum β-lactamase genes. Presumed non-immune post-traumatic DAH with possible TRALI contribution was diagnosed. Treatment included withholding further transfusion, methylprednisolone 1 mg/kg/day, lung-protective ventilation, four prolonged prone-positioning sessions, antimicrobial therapy and damage-control orthopaedics, with definitive fixation on day 17. Tracheostomy was decannulated on day 28, and he was discharged to rehabilitation. At follow-up, he walked independently without recurrent DAH or ARDS.Conclusions
In polytrauma patients, new diffuse airway bleeding, disproportionate anaemia and worsening hypoxaemia should prompt consideration of non-immune DAH, particularly after transfusion. In this single case, recovery followed a combined strategy of bronchoscopic assessment, restrictive transfusion, corticosteroids, prone ventilation and physiology-guided orthopaedic management. However, concurrent interventions and the absence of histological confirmation preclude causal attribution; the findings are hypothesis-generating.
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BibTeX
@article{huang2026diffuse,
title = {{Diffuse Alveolar Haemorrhage Masquerading as Worsening ARDS in a Young Polytrauma Patient: Diagnostic Reasoning and a Conservative Management Bundle - A Case Report.}},
author = {Zhaolve Huang and Minghao Yang and Jishen Luo and Chao Liu},
journal = {Patient preference and adherence},
year = {2026},
month = oct,
doi = {10.2147/ppa.s639654},
url = {https://europepmc.org/article/MED/42921504},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Diffuse Alveolar Haemorrhage Masquerading as Worsening ARDS in a Young Polytrauma Patient: Diagnostic Reasoning and a Conservative Management Bundle - A Case Report.
AU - Zhaolve Huang
AU - Minghao Yang
AU - Jishen Luo
AU - Chao Liu
PY - 2026
DA - 2026/10/19
JO - Patient preference and adherence
DO - 10.2147/ppa.s639654
UR - https://europepmc.org/article/MED/42921504
AB - Background Diffuse alveolar haemorrhage (DAH) is a rare, under-recognised complication of blunt polytrauma. In patients with severe acute respiratory distress syndrome (ARDS), new airway bleeding may be mistaken for pulmonary contusion, ventilator-associated pneumonia or transfusion-related acute lung injury (TRALI), delaying appropriate treatment. The timing of definitive fracture fixation also remains uncertain.Case presentation A previously healthy man in his mid-20s sustained blunt polytrauma (Injury Severity Score 29; Glasgow Coma Scale 8), including multiple open comminuted fractures, a T11 compression fracture and bilateral pulmonary contusions. After emergency external fixation, he was transferred in haemorrhagic shock and respiratory failure, with severe ARDS (PaO₂/FiO₂ 78 mmHg), lactate 7.0 mmol/L and creatine kinase 4443 U/L. On day 4, he developed bloody endotracheal secretions, recurrent hypoxaemia, and abrupt decreases in haemoglobin (114 to 76 g/L) and platelets (139 to 65 × 10⁹/L). Bronchoscopy showed diffuse, non-focal mucosal oozing. Vasculitis and cytokine panels were negative. Targeted next-generation sequencing of bronchoalveolar lavage fluid detected high burdens of Acinetobacter baumannii and Klebsiella pneumoniae, low-abundance Pseudomonas aeruginosa, and multiple carbapenemase and extended-spectrum β-lactamase genes. Presumed non-immune post-traumatic DAH with possible TRALI contribution was diagnosed. Treatment included withholding further transfusion, methylprednisolone 1 mg/kg/day, lung-protective ventilation, four prolonged prone-positioning sessions, antimicrobial therapy and damage-control orthopaedics, with definitive fixation on day 17. Tracheostomy was decannulated on day 28, and he was discharged to rehabilitation. At follow-up, he walked independently without recurrent DAH or ARDS.Conclusions In polytrauma patients, new diffuse airway bleeding, disproportionate anaemia and worsening hypoxaemia should prompt consideration of non-immune DAH, particularly after transfusion. In this single case, recovery followed a combined strategy of bronchoscopic assessment, restrictive transfusion, corticosteroids, prone ventilation and physiology-guided orthopaedic management. However, concurrent interventions and the absence of histological confirmation preclude causal attribution; the findings are hypothesis-generating.
SN - 1177-889X
ER -