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PreprintCC BYChemRxiv

Decoding Rotavirus Cell Entry through the Lens of Vesicle Budding-and-Collapse

  • Dehua Pei
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Abstract

How nonenveloped viruses cross host membranes without causing cell lysis remains a central biophysical paradox. A recent cryogenic electron tomography study by de Sautu et al. proposed that rhesus rotavirus double-layered particles (DLPs) escape endocytic vesicles through a large, VP7-stabilized membrane pore. However, a static pore model is difficult to reconcile with live-cell single-particle tracking data showing multi-minute lags between VP7 dissociation and DLP release. Here, I show that these structural snapshots map onto the vesicle budding-and-collapse (VBC) framework, a recently discovered mechanism shared by a growing number of biological and synthetic membrane-translocation systems. Re-interpreting rotavirus entry through VBC resolves kinetic discrepancies in the literature and provides a unified physical paradigm for viral entry and drug delivery.

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Cite

BibTeXRIS
BibTeX
@misc{pei2026decoding,
  title = {{Decoding Rotavirus Cell Entry through the Lens of Vesicle Budding-and-Collapse}},
  author = {Dehua Pei},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009704/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009704/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Decoding Rotavirus Cell Entry through the Lens of Vesicle Budding-and-Collapse
AU  - Dehua Pei
PY  - 2026
DA  - 2026/09/30
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009704/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009704/v1
AB  - How nonenveloped viruses cross host membranes without causing cell lysis remains a central biophysical paradox. A recent cryogenic electron tomography study by de Sautu et al. proposed that rhesus rotavirus double-layered particles (DLPs) escape endocytic vesicles through a large, VP7-stabilized membrane pore. However, a static pore model is difficult to reconcile with live-cell single-particle tracking data showing multi-minute lags between VP7 dissociation and DLP release. Here, I show that these structural snapshots map onto the vesicle budding-and-collapse (VBC) framework, a recently discovered mechanism shared by a growing number of biological and synthetic membrane-translocation systems. Re-interpreting rotavirus entry through VBC resolves kinetic discrepancies in the literature and provides a unified physical paradigm for viral entry and drug delivery.
ER  -