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Peer-reviewedCC BYAdvances in Oral and Maxillofacial Surgery

Efficacy of cryotherapy as an adjunctive treatment for mandibular central giant cell granuloma: A case series

  • Richard Yang1
  • Jason Middleton2
  • Heshaam Fallah3
  1. 1Department of Oral and Maxillofacial Surgery, Highland Hospital, Alameda Health System, Oakland, CA, USA
  2. 2Department of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA; Corresponding author. 3600 Broadway St., 4th Floor Suite 41, Oakland, CA 94611, USA.
  3. 3Department of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA
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Abstract

This case series examines the clinical and radiographic outcomes of central giant cell granulomas (CGCG) of the mandible treated with enucleation, liquid nitrogen cryotherapy, and recombinant human bone morphogenetic protein-2 (rhBMP-2) augmented bone grafting. Five patients were treated with this surgical technique. All patients demonstrated complete radiographic ossification within 6–12 months, without recurrence or major complication. In all patients whose dentition was resected with the pathologic bone (2 of 5), complete dental rehabilitation was achieved, demonstrating functional bone regeneration. This series represents a reliable middle ground between curettage and segmental resection.

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Cite

BibTeXRIS
BibTeX
@article{yang2026efficacy,
  title = {{Efficacy of cryotherapy as an adjunctive treatment for mandibular central giant cell granuloma: A case series}},
  author = {Richard Yang and Jason Middleton and Heshaam Fallah},
  journal = {Advances in Oral and Maxillofacial Surgery},
  year = {2026},
  month = oct,
  doi = {10.1016/j.adoms.2026.100738},
  url = {https://doi.org/10.1016/j.adoms.2026.100738},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Efficacy of cryotherapy as an adjunctive treatment for mandibular central giant cell granuloma: A case series
AU  - Richard Yang
AU  - Jason Middleton
AU  - Heshaam Fallah
PY  - 2026
DA  - 2026/10/30
JO  - Advances in Oral and Maxillofacial Surgery
DO  - 10.1016/j.adoms.2026.100738
UR  - https://doi.org/10.1016/j.adoms.2026.100738
AB  - This case series examines the clinical and radiographic outcomes of central giant cell granulomas (CGCG) of the mandible treated with enucleation, liquid nitrogen cryotherapy, and recombinant human bone morphogenetic protein-2 (rhBMP-2) augmented bone grafting. Five patients were treated with this surgical technique. All patients demonstrated complete radiographic ossification within 6–12 months, without recurrence or major complication. In all patients whose dentition was resected with the pathologic bone (2 of 5), complete dental rehabilitation was achieved, demonstrating functional bone regeneration. This series represents a reliable middle ground between curettage and segmental resection.
SN  - 2667-1476
ER  -