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Peer-reviewedCC BYFrontiers in Medicine

Multimodal analgesic regimen is associated with earlier bowel recovery in infants undergoing liver transplantation: a cohort study

  • Ling Zhu1
  • Ling Zhu2
  • Jiabei He1
  • Jiabei He2
  • Leiqing Gao3
  • Yuxiao Deng4
  • Bo Qi1
  • Bo Qi2
4 affiliations
  1. 1Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. 2Key Laboratory of Anesthesiology, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
  3. 3Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  4. 4Department of Critical Care Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Abstract

PurposeThis study aims to compare the effects of a multimodal analgesia regimen including sufentanil, esketamine, and dexmedetomidine with the traditional morphine-only analgesia approach on postoperative bowel recovery in pediatric liver transplant patients.MethodsThis is a single-center retrospective cohort study. The medical records of a total of 82 infants who underwent liver transplantation at Renji Hospital, from September 2022 to March 2023 were included. Patients were divided into two groups based on the postoperative analgesia regimen: the morphine group (M group), which used morphine only, and the multimodal analgesia group (MMA group), which used sufentanil in combination with esketamine and dexmedetomidine.ResultsThe patients’ ages ranged from 4 to 12 months, and the mean preoperative pediatric end-stage liver disease (PELD) scores were 18.7 and 21.9. General linear model analysis revealed that the MMA group had a significantly shorter time to first bowel movement and shorter mechanical ventilation duration. Multivariate analysis further indicated that the use of multimodal analgesia significantly accelerated time to first defecation by approximately 20.6 h.ConclusionCompared to using morphine alone for postoperative analgesia, the combination of sufentanil, esketamine, and dexmedetomidine for postoperative analgesia in liver transplant infants is more beneficial for brecovery and facilitates early postoperative extubation.

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Cite

BibTeXRIS
BibTeX
@article{zhu2026multimodal,
  title = {{Multimodal analgesic regimen is associated with earlier bowel recovery in infants undergoing liver transplantation: a cohort study}},
  author = {Ling Zhu and Ling Zhu and Jiabei He and Jiabei He and Leiqing Gao and Yuxiao Deng and Bo Qi and Bo Qi},
  journal = {Frontiers in Medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fmed.2026.1962570},
  url = {https://doi.org/10.3389/fmed.2026.1962570},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Multimodal analgesic regimen is associated with earlier bowel recovery in infants undergoing liver transplantation: a cohort study
AU  - Ling Zhu
AU  - Ling Zhu
AU  - Jiabei He
AU  - Jiabei He
AU  - Leiqing Gao
AU  - Yuxiao Deng
AU  - Bo Qi
AU  - Bo Qi
PY  - 2026
DA  - 2026/10/23
JO  - Frontiers in Medicine
DO  - 10.3389/fmed.2026.1962570
UR  - https://doi.org/10.3389/fmed.2026.1962570
AB  - PurposeThis study aims to compare the effects of a multimodal analgesia regimen including sufentanil, esketamine, and dexmedetomidine with the traditional morphine-only analgesia approach on postoperative bowel recovery in pediatric liver transplant patients.MethodsThis is a single-center retrospective cohort study. The medical records of a total of 82 infants who underwent liver transplantation at Renji Hospital, from September 2022 to March 2023 were included. Patients were divided into two groups based on the postoperative analgesia regimen: the morphine group (M group), which used morphine only, and the multimodal analgesia group (MMA group), which used sufentanil in combination with esketamine and dexmedetomidine.ResultsThe patients’ ages ranged from 4 to 12 months, and the mean preoperative pediatric end-stage liver disease (PELD) scores were 18.7 and 21.9. General linear model analysis revealed that the MMA group had a significantly shorter time to first bowel movement and shorter mechanical ventilation duration. Multivariate analysis further indicated that the use of multimodal analgesia significantly accelerated time to first defecation by approximately 20.6 h.ConclusionCompared to using morphine alone for postoperative analgesia, the combination of sufentanil, esketamine, and dexmedetomidine for postoperative analgesia in liver transplant infants is more beneficial for brecovery and facilitates early postoperative extubation.
SN  - 2296-858X
ER  -