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Peer-reviewedCC BY 4.0PLOS One

Choroid plexus volume variation in patients with gliomas, glioneuronal and neuronal tumors: Associations with tumor characteristics

  • Jia Sun1
  • Minghao Wu2
  • Junjie Li3
  • Jinyuan Weng4
  • Renlong Zhang5
  • Yuanbin Zhao6
  • Xiaoqin Zhu7
  • Mengzhao Li8
  • Yunyun Duan
  • Cong Zhang
  • Dongli Shi
8 affiliations
  1. 1Department of Radiology, Peking University Third Hospital, Beijing, China
  2. 2Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  3. 3Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Interventional Therapy, Peking University Cancer Hospital, Beijing, China
  4. 4Department of Clinical and Technical Support, Philips Healthcare, Shanghai, China
  5. 5Institute of Research and Clinical Innovations, Neusoft Medical Systems Co., Ltd., Beijing, China
  6. 6Department of Radiology, Tianjin Key Laboratory of Functional Imaging, and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China
  7. 7Department of Internal Medicine II, Rongcheng County People’s Hospital, Xiongan New Area, Hebei, China
  8. 8Department of Neurology, theSecond Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
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Abstract

Purpose: To investigate choroid plexus . volume (CPV) alterations in patients with gliomas and glioneuronal and neuronal tumors (GNTs) and to evaluate their associations with tumor characteristics. Methods: In this retrospective observational cohort study, 811 patients with histologically confirmed brain tumors (674 gliomas and 137 GNTs) and 744 controls were included. All participants underwent 3.0 T MRI with 3D T1-weighted imaging, and patient scans were acquired preoperatively. The choroid plexus was automatically segmented on 3D T1-weighted images using a 3D nnU-Net–based deep learning algorithm with expert quality control. CPV was normalized to total intracranial volume (CPV/TIV). Lateral ventricular volume (LVV) was quantified using FreeSurfer and included as a covariate. Group comparisons were performed using Mann–Whitney U and Kruskal–Wallis tests after case-control matching. Multivariable linear regression analyses were conducted to assess independent associations while adjusting for age, sex, and LVV, with additional sensitivity analyses incorporating scanner type. Results: Compared with supratentorial tumors and controls, infratentorial tumors showed significantly larger CPV (both P < 0.001). Tumor grade was not independently associated with CPV after adjustment among patients. Pediatric-type diffuse high-grade gliomas and GNTs exhibited larger CPV than adult-type diffuse gliomas (P < 0.01). In exploratory molecular analyses of adult-type diffuse gliomas, + 7/ − 10 status was associated with lower CPV (β = −0.127, P = 0.009). Conclusion: CPV alterations in brain tumors are primarily associated with tumor location and histological classification rather than tumor grade. An exploratory association between +7/ − 10 status and lower CPV was also observed, although this finding requires further validation.

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Cite

BibTeXRIS
BibTeX
@article{sun2026choroid,
  title = {{Choroid plexus volume variation in patients with gliomas, glioneuronal and neuronal tumors: Associations with tumor characteristics}},
  author = {Jia Sun and Minghao Wu and Junjie Li and Jinyuan Weng and Renlong Zhang and Yuanbin Zhao and Xiaoqin Zhu and Mengzhao Li and Yunyun Duan and Cong Zhang and Dongli Shi},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0357498},
  url = {https://doi.org/10.1371/journal.pone.0357498},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Choroid plexus volume variation in patients with gliomas, glioneuronal and neuronal tumors: Associations with tumor characteristics
AU  - Jia Sun
AU  - Minghao Wu
AU  - Junjie Li
AU  - Jinyuan Weng
AU  - Renlong Zhang
AU  - Yuanbin Zhao
AU  - Xiaoqin Zhu
AU  - Mengzhao Li
AU  - Yunyun Duan
AU  - Cong Zhang
AU  - Dongli Shi
PY  - 2026
DA  - 2026/09/15
JO  - PLOS One
DO  - 10.1371/journal.pone.0357498
UR  - https://doi.org/10.1371/journal.pone.0357498
AB  - Purpose: To investigate choroid plexus . volume (CPV) alterations in patients with gliomas and glioneuronal and neuronal tumors (GNTs) and to evaluate their associations with tumor characteristics. Methods: In this retrospective observational cohort study, 811 patients with histologically confirmed brain tumors (674 gliomas and 137 GNTs) and 744 controls were included. All participants underwent 3.0 T MRI with 3D T1-weighted imaging, and patient scans were acquired preoperatively. The choroid plexus was automatically segmented on 3D T1-weighted images using a 3D nnU-Net–based deep learning algorithm with expert quality control. CPV was normalized to total intracranial volume (CPV/TIV). Lateral ventricular volume (LVV) was quantified using FreeSurfer and included as a covariate. Group comparisons were performed using Mann–Whitney U and Kruskal–Wallis tests after case-control matching. Multivariable linear regression analyses were conducted to assess independent associations while adjusting for age, sex, and LVV, with additional sensitivity analyses incorporating scanner type. Results: Compared with supratentorial tumors and controls, infratentorial tumors showed significantly larger CPV (both P < 0.001). Tumor grade was not independently associated with CPV after adjustment among patients. Pediatric-type diffuse high-grade gliomas and GNTs exhibited larger CPV than adult-type diffuse gliomas (P < 0.01). In exploratory molecular analyses of adult-type diffuse gliomas, + 7/ − 10 status was associated with lower CPV (β = −0.127, P = 0.009). Conclusion: CPV alterations in brain tumors are primarily associated with tumor location and histological classification rather than tumor grade. An exploratory association between +7/ − 10 status and lower CPV was also observed, although this finding requires further validation.
SN  - 1932-6203
ER  -