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Peer-reviewedCC BY-NC-NDBMC research notes

Effects of local vibration therapy and gabapentin on restless legs syndrome symptoms: a randomized controlled trial.

  • Gholamreza Raissi1
  • Bijan Forogh2
  • Hamid Ansari3
  • Seyed Pezhman Madani1
  • Masumeh Bagherzadeh Cham4
  • Hosna Soleymanzadeh1
4 affiliations
  1. 1Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  2. 2Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. [email protected].
  3. 3Neuromusculoskeletal Research Center, Department of Physical Medicine and Rehabilitation, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. [email protected].
  4. 4Clinical Biomechanics and Ergonomics Research Center, Department of Physical Medicine and Rehabilitation, AJA University of Medical Sciences, Tehran, Iran.
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Abstract

Objective

This study aimed to evaluate the effect of LV in combination with gabapentin, a first-line medication for RLS, on the treatment of patients with the condition.Results

In total, 36 participants (18 in each group) participated in this study, with 10 (55%) being male within each group. The mean age of participants was 45 years (SD = 10.6) in the LV group and 49.1 (SD = 8.3) in the gabapentin group. In both the LV and gabapentin groups, IRLSSG scores decreased significantly after the intervention compared with baseline (p < 0.001). However, scores increased at the one-month follow-up, although they remained lower than pre-intervention values (p < 0.001). A similar pattern was observed for the PSQI scores (p < 0.001). There were no significant differences between groups at any timepoint (p > 0.05).Trial registration

The study protocol was registered at the Iranian Registry of Clinical Trials on August 30th, 2023 (code IRCT20190306042945N4).

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Cite

BibTeXRIS
BibTeX
@article{raissi2026effects,
  title = {{Effects of local vibration therapy and gabapentin on restless legs syndrome symptoms: a randomized controlled trial.}},
  author = {Gholamreza Raissi and Bijan Forogh and Hamid Ansari and Seyed Pezhman Madani and Masumeh Bagherzadeh Cham and Hosna Soleymanzadeh},
  journal = {BMC research notes},
  year = {2026},
  month = jul,
  doi = {10.1186/s13104-026-07918-z},
  url = {https://europepmc.org/article/MED/42908006},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Effects of local vibration therapy and gabapentin on restless legs syndrome symptoms: a randomized controlled trial.
AU  - Gholamreza Raissi
AU  - Bijan Forogh
AU  - Hamid Ansari
AU  - Seyed Pezhman Madani
AU  - Masumeh Bagherzadeh Cham
AU  - Hosna Soleymanzadeh
PY  - 2026
DA  - 2026/07/01
JO  - BMC research notes
DO  - 10.1186/s13104-026-07918-z
UR  - https://europepmc.org/article/MED/42908006
AB  - Objective  This study aimed to evaluate the effect of LV in combination with gabapentin, a first-line medication for RLS, on the treatment of patients with the condition.Results  In total, 36 participants (18 in each group) participated in this study, with 10 (55%) being male within each group. The mean age of participants was 45 years (SD = 10.6) in the LV group and 49.1 (SD = 8.3) in the gabapentin group. In both the LV and gabapentin groups, IRLSSG scores decreased significantly after the intervention compared with baseline (p < 0.001). However, scores increased at the one-month follow-up, although they remained lower than pre-intervention values (p < 0.001). A similar pattern was observed for the PSQI scores (p < 0.001). There were no significant differences between groups at any timepoint (p > 0.05).Trial registration  The study protocol was registered at the Iranian Registry of Clinical Trials on August 30th, 2023 (code IRCT20190306042945N4).
SN  - 1756-0500
ER  -