Hematological, biochemical, and oxidative stress changes in lambs with atresia ani
4 affiliations
- 1DVM Graduate, Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
- 2Department of Clinical Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
- 3Department of Clinical Science, Faculty of Veterinary Medicine, Islamic Azad University, Garmsar Branch, Garmsar, Iran
- 4Resident of Veterinary Surgery and Anesthesia, Department of Clinical Science, Faculty of Veterinary Medicine, Ferdowsi University, Mashhad, Iran.
Abstract
Anal atresia (AA) is a congenital anorectal malformation in neonatal lambs characterized by failure of the anal membrane to perforate, resulting in the absence of an anal opening. Early diagnosis and surgical correction are essential for improving survival and outcomes. This study evaluated hematobiochemical and oxidative stress parameters in neonatal lambs with non-segmental AA undergoing surgical intervention. Forty-five male lambs diagnosed with non-segmental AA were enrolled and stratified by time of presentation: within 24 hours of birth or 24-72 hours. An additional 45 healthy male lambs served as controls. Hematological and biochemical parameters, including white blood cell count, red blood cell count, hemoglobin, packed cell volume, total protein, C-reactive protein, superoxide dismutase, malondialdehyde, globulin, fibrinogen, and urea were measured at presentation and 3 days post-operatively. All AA lambs underwent surgical correction, with clinical follow-up for 30 days. Significant differences in hematobiochemical indices and oxidative stress markers were observed between AA lambs and healthy controls. Early surgical intervention (within 24 hours) was associated with significantly reduced levels of urea, fibrinogen, and C-reactive protein. It also resulted in lower malondialdehyde concentrations and higher superoxide dismutase activity, indicating decreased oxidative stress and inflammation compared with later intervention. These findings highlight the critical importance of early surgical intervention in neonatal lambs with anal atresia. Timely surgery improves hematological stability, mitigates oxidative damage, and supports better overall recovery.
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BibTeX
@article{hafezian2026hematological,
title = {{Hematological, biochemical, and oxidative stress changes in lambs with atresia ani}},
author = {Seyed Amir Hossein Hafezian and Abbas Raisi and Meysam Tehrani-Sharif and Khosro Safari Nikroo and Amir Zakian},
journal = {Veterinary Research Forum},
year = {2026},
month = jul,
doi = {10.30466/vrf.2025.2065164.4822},
url = {https://doi.org/10.30466/vrf.2025.2065164.4822},
note = {CC BY-NC-SA 4.0},
}
RIS
TY - JOUR
TI - Hematological, biochemical, and oxidative stress changes in lambs with atresia ani
AU - Seyed Amir Hossein Hafezian
AU - Abbas Raisi
AU - Meysam Tehrani-Sharif
AU - Khosro Safari Nikroo
AU - Amir Zakian
PY - 2026
DA - 2026/07/15
JO - Veterinary Research Forum
DO - 10.30466/vrf.2025.2065164.4822
UR - https://doi.org/10.30466/vrf.2025.2065164.4822
AB - Anal atresia (AA) is a congenital anorectal malformation in neonatal lambs characterized by failure of the anal membrane to perforate, resulting in the absence of an anal opening. Early diagnosis and surgical correction are essential for improving survival and outcomes. This study evaluated hematobiochemical and oxidative stress parameters in neonatal lambs with non-segmental AA undergoing surgical intervention. Forty-five male lambs diagnosed with non-segmental AA were enrolled and stratified by time of presentation: within 24 hours of birth or 24-72 hours. An additional 45 healthy male lambs served as controls. Hematological and biochemical parameters, including white blood cell count, red blood cell count, hemoglobin, packed cell volume, total protein, C-reactive protein, superoxide dismutase, malondialdehyde, globulin, fibrinogen, and urea were measured at presentation and 3 days post-operatively. All AA lambs underwent surgical correction, with clinical follow-up for 30 days. Significant differences in hematobiochemical indices and oxidative stress markers were observed between AA lambs and healthy controls. Early surgical intervention (within 24 hours) was associated with significantly reduced levels of urea, fibrinogen, and C-reactive protein. It also resulted in lower malondialdehyde concentrations and higher superoxide dismutase activity, indicating decreased oxidative stress and inflammation compared with later intervention. These findings highlight the critical importance of early surgical intervention in neonatal lambs with anal atresia. Timely surgery improves hematological stability, mitigates oxidative damage, and supports better overall recovery.
SN - 2008-8140
SN - 2322-3618
ER -