Lipid Nanoparticles at the Crossroads of Chemistry and Medicine: A Tutorial.
- 1Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
- 2Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Abstract
Lipid nanoparticles (LNPs) have risen to the forefront of modern therapeutics by enabling the clinical success of COVID-19 mRNA vaccines. In order for them to function as drug delivery vesicles, LNPs must have scalable, tunable, and targeted nanoscale platforms whose strengths in versatility, performance, and clinical relevance are driven by key design parameters and formulation strategies. This Tutorial Review traces the historical evolution of LNPs and examines the fundamental design principles governing their structure, physicochemical properties, and biological behavior. It further highlights modern analytical characterization techniques that have advanced mechanistic understanding of LNP composition, morphology, and function as well as targeting strategies to improve LNP delivery to extrahepatic sites. Current translational challenges and emerging advances are also discussed. This Tutorial Review provides a framework for understanding the foundations, current landscape, and future directions of LNP research.
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BibTeX
@article{rogado2026lipid,
title = {{Lipid Nanoparticles at the Crossroads of Chemistry and Medicine: A Tutorial.}},
author = {Myxie Tana Rogado and Audrey Wang and Sophia Zeng and Zhenghe Wang and Clemens Burda},
journal = {ACS nanoscience Au},
year = {2026},
month = sep,
doi = {10.1021/acsnanoscienceau.6c00096},
url = {https://europepmc.org/article/MED/42921289},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Lipid Nanoparticles at the Crossroads of Chemistry and Medicine: A Tutorial.
AU - Myxie Tana Rogado
AU - Audrey Wang
AU - Sophia Zeng
AU - Zhenghe Wang
AU - Clemens Burda
PY - 2026
DA - 2026/09/28
JO - ACS nanoscience Au
DO - 10.1021/acsnanoscienceau.6c00096
UR - https://europepmc.org/article/MED/42921289
AB - Lipid nanoparticles (LNPs) have risen to the forefront of modern therapeutics by enabling the clinical success of COVID-19 mRNA vaccines. In order for them to function as drug delivery vesicles, LNPs must have scalable, tunable, and targeted nanoscale platforms whose strengths in versatility, performance, and clinical relevance are driven by key design parameters and formulation strategies. This Tutorial Review traces the historical evolution of LNPs and examines the fundamental design principles governing their structure, physicochemical properties, and biological behavior. It further highlights modern analytical characterization techniques that have advanced mechanistic understanding of LNP composition, morphology, and function as well as targeting strategies to improve LNP delivery to extrahepatic sites. Current translational challenges and emerging advances are also discussed. This Tutorial Review provides a framework for understanding the foundations, current landscape, and future directions of LNP research.
SN - 2694-2496
ER -