Efficient Propranolol Delivery Enabled by Manganese‐Based Bioactive Metal–Organic Frameworks With High Loading Capacity
- 1Department of Inorganic Chemistry Faculty of Chemistry University of Guilan Rasht Iran
- 2Chemical Engineering Department University of Kashan Kashan Iran
- 3Department of Chemistry University of Turin Turin Italy
Abstract
A green and efficient method was developed for propranolol delivery utilizing manganese‐based bioactive metal–organic frameworks (MOFs) as biocompatible drug carriers. Mn‐based bioactive MOFs with a high aspect ratio were synthesized and characterized for size (average, 17 µm), morphology, stability, elemental composition, crystallinity, functionality, charge character, and biocompatibility (a protein adsorption capacity of 0.03 µg µg ⁻¹ (5 h) and a hemolysis ratio of < 0.5%). Afterward, the MOFs were utilized for drug loading via an encapsulation method, and the drug release studies were also performed. The drug loading was confirmed using the zeta potential, CHN analysis, and thermogravimetric analysis (TGA) measurements. An encapsulation efficiency of 96% (0.5 W/W (drug/MOFs)) and a maximal capacity ( Q max ) of 0.526 mg mg ⁻¹ were obtained. The drug release showed that 93.72% of the loaded drug was released after 10 h for a composite of 0.25 W/W (drug/MOFs), while for 0.5 W/W (drug/MOFs), the drug release reached a plateau after 3 h. The kinetic studies showed longer release times and higher release rates for higher drug loading efficiency. Overall, herein, a bioactive platform for efficient delivery of propranolol was developed to improve the therapeutic efficacy by enhancing the drug loading and achieving controlled drug release.
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BibTeX
@article{borhanipasvisheh2026efficient,
title = {{Efficient Propranolol Delivery Enabled by Manganese‐Based Bioactive Metal–Organic Frameworks With High Loading Capacity}},
author = {Hanieh Borhanipasvisheh and Soheil Dehghani Siyahaki and Elham Gholamhosseinzadeh},
journal = {ChemistryOpen},
year = {2026},
month = oct,
doi = {10.1002/open.70319},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.70319},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Efficient Propranolol Delivery Enabled by Manganese‐Based Bioactive Metal–Organic Frameworks With High Loading Capacity
AU - Hanieh Borhanipasvisheh
AU - Soheil Dehghani Siyahaki
AU - Elham Gholamhosseinzadeh
PY - 2026
DA - 2026/10/18
JO - ChemistryOpen
DO - 10.1002/open.70319
UR - https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/open.70319
AB - A green and efficient method was developed for propranolol delivery utilizing manganese‐based bioactive metal–organic frameworks (MOFs) as biocompatible drug carriers. Mn‐based bioactive MOFs with a high aspect ratio were synthesized and characterized for size (average, 17 µm), morphology, stability, elemental composition, crystallinity, functionality, charge character, and biocompatibility (a protein adsorption capacity of 0.03 µg µg ⁻¹ (5 h) and a hemolysis ratio of < 0.5%). Afterward, the MOFs were utilized for drug loading via an encapsulation method, and the drug release studies were also performed. The drug loading was confirmed using the zeta potential, CHN analysis, and thermogravimetric analysis (TGA) measurements. An encapsulation efficiency of 96% (0.5 W/W (drug/MOFs)) and a maximal capacity ( Q max ) of 0.526 mg mg ⁻¹ were obtained. The drug release showed that 93.72% of the loaded drug was released after 10 h for a composite of 0.25 W/W (drug/MOFs), while for 0.5 W/W (drug/MOFs), the drug release reached a plateau after 3 h. The kinetic studies showed longer release times and higher release rates for higher drug loading efficiency. Overall, herein, a bioactive platform for efficient delivery of propranolol was developed to improve the therapeutic efficacy by enhancing the drug loading and achieving controlled drug release.
SN - 2191-1363
SN - 2191-1363
ER -