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Peer-reviewedCC BYInternational journal of molecular sciences

Gamma-Oryzanol Solid Dispersion Attenuates Dexamethasone-Induced Depressive-like Behaviors in Rats Associated with Calbindin-1 and Calcium Signaling.

  • Siripaporn Kesyou1,2
  • Waree Tiyaboonchai3,4
  • Jureepon Roboon4,5,6
  • Paweena Kaewman4,5,6
  • Sawanya Charoenlappanit7
  • Sittiruk Roytrakul7
  • Vincent Van Waes2
  • Gavin P Reynolds6,8
  • Samur Thanoi9
  • Sutisa Nudmamud-Thanoi4,5,6
9 affiliations
  1. 1Faculty of Medical Science, Medical Science Graduate Program, Naresuan University, Phitsanulok 65000, Thailand.
  2. 2INSERM, UMR 1322 LINC, Université Marie et Louis Pasteur, F-25000 Besançon, France.
  3. 3Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
  4. 4Frontier Research Cluster in Brain Health, Naresuan University, Phitsanulok 65000, Thailand.
  5. 5Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
  6. 6Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.
  7. 7National Centre for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
  8. 8Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield S1 1WB, UK.
  9. 9School of Medical Sciences, University of Phayao, Phayao 56000, Thailand.
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Abstract

Depression is associated with dysfunction of the hypothalamic-pituitary-adrenal axis, neurotransmitter imbalance, and calcium signaling deficits. Although gamma-oryzanol (GO) has shown antidepressant effects, its underlying molecular mechanism remains elusive, while its poor aqueous solubility limits its nutraceutical application. To overcome this obstacle, we successfully developed GO solid dispersion (GOSD) with enhanced water solubility for nutraceutical formulations. This study examined the antidepressant effect of GOSD in dexamethasone (Dx)-induced depressive-like behaviors in rats using behavioral tests, including the sucrose preference test and forced-swimming test (FST). The Dx group showed a reduction in sucrose consumption and mobility time in the FST compared with controls, both of which improved following GOSD administration. Proteomics revealed changes associated with the calcium signaling pathway. Calbindin (Calb1) expression was reduced in the Dx group, whereas GOSD administration restored Calb1 levels. Given the role of Calb1, a calcium-binding protein (CBP) involved in intracellular calcium buffering, reduced Calb1 expression in the Dx group may contribute to calcium signaling dysregulation. In contrast, GOSD can attenuate Calb1 levels, which potentially contribute to its antidepressant effects. These findings suggest that the antidepressant-like effects of GOSD may involve modulation of calcium homeostasis, supporting its potential as a complementary intervention for Dx-induced depressive-like behaviors.

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Cite

BibTeXRIS
BibTeX
@article{kesyou2026gammaoryzanol,
  title = {{Gamma-Oryzanol Solid Dispersion Attenuates Dexamethasone-Induced Depressive-like Behaviors in Rats Associated with Calbindin-1 and Calcium Signaling.}},
  author = {Siripaporn Kesyou and Waree Tiyaboonchai and Jureepon Roboon and Paweena Kaewman and Sawanya Charoenlappanit and Sittiruk Roytrakul and Vincent Van Waes and Gavin P Reynolds and Samur Thanoi and Sutisa Nudmamud-Thanoi},
  journal = {International journal of molecular sciences},
  year = {2026},
  month = sep,
  doi = {10.3390/ijms27198721},
  url = {https://europepmc.org/article/MED/42883962},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Gamma-Oryzanol Solid Dispersion Attenuates Dexamethasone-Induced Depressive-like Behaviors in Rats Associated with Calbindin-1 and Calcium Signaling.
AU  - Siripaporn Kesyou
AU  - Waree Tiyaboonchai
AU  - Jureepon Roboon
AU  - Paweena Kaewman
AU  - Sawanya Charoenlappanit
AU  - Sittiruk Roytrakul
AU  - Vincent Van Waes
AU  - Gavin P Reynolds
AU  - Samur Thanoi
AU  - Sutisa Nudmamud-Thanoi
PY  - 2026
DA  - 2026/09/29
JO  - International journal of molecular sciences
DO  - 10.3390/ijms27198721
UR  - https://europepmc.org/article/MED/42883962
AB  - Depression is associated with dysfunction of the hypothalamic-pituitary-adrenal axis, neurotransmitter imbalance, and calcium signaling deficits. Although gamma-oryzanol (GO) has shown antidepressant effects, its underlying molecular mechanism remains elusive, while its poor aqueous solubility limits its nutraceutical application. To overcome this obstacle, we successfully developed GO solid dispersion (GOSD) with enhanced water solubility for nutraceutical formulations. This study examined the antidepressant effect of GOSD in dexamethasone (Dx)-induced depressive-like behaviors in rats using behavioral tests, including the sucrose preference test and forced-swimming test (FST). The Dx group showed a reduction in sucrose consumption and mobility time in the FST compared with controls, both of which improved following GOSD administration. Proteomics revealed changes associated with the calcium signaling pathway. Calbindin (Calb1) expression was reduced in the Dx group, whereas GOSD administration restored Calb1 levels. Given the role of Calb1, a calcium-binding protein (CBP) involved in intracellular calcium buffering, reduced Calb1 expression in the Dx group may contribute to calcium signaling dysregulation. In contrast, GOSD can attenuate Calb1 levels, which potentially contribute to its antidepressant effects. These findings suggest that the antidepressant-like effects of GOSD may involve modulation of calcium homeostasis, supporting its potential as a complementary intervention for Dx-induced depressive-like behaviors.
SN  - 1422-0067
ER  -