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Peer-reviewedCC BY-NCRSC advances

Batch sequential production of medicated Janus fibrous films of polyvinylpyrrolidone/shellac for treating pharyngitis

  • Xiaomin Yu1
  • Yuxuan Xu2
  • Bo Wang3
  • Deng-Guang Yu2
  • Ming Zhang1
  • Yuanjie Zhu3
  1. 1School of Materials Science and Engineering, Zhejiang Sci-Tech University Hangzhou 310000 China
  2. 2Department of Dermatology, Naval Medical Center, Naval Medical University Shanghai 200052 China
  3. 3Department of Dermatology, Changhai Hospital, Naval Medical University Shanghai 200433 China
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Abstract

Janus structures are highly popular for developing functional materials, including drug delivery systems, whereas batch production of Janus fibrous films represents one of the most difficult challenges. Here, based on a brand-new integrated multi-orifice spinneret, Janus fibrous films were fabricated directly through a sequential batch electrospinning process. The films contained a top layer of polyvinylpyrrolidone (PVP), borneol, sucralose, and acetaminophen (APAP) for rapid drug release, and a bottom layer of shellac, PVP, borneol, sucralose, and APAP for sustained drug release. Scanning electron microscopy results verified that both the top and bottom layers were composed of ultra-thin linear fibers without beads or spindles. X-ray diffraction and Fourier-transform infrared spectroscopy results verified that borneol and APAP were present in the Janus films in an amorphous state and exhibited good compatibility with the polymeric matrices. The Janus fibrous films can be cut into small patches for topical administration to treat pharyngitis. Artificial tongue and saliva models were exploited to conduct in vitro dissolution tests. Biphasic release of the loaded APAP from the artificial tongue surface was demonstrated. The mechanism underlying the new technique-based process–structure–performance relationship was proposed. The reported protocols provide a brand-new approach for batch creating Janus fibrous films, which can be further exploited for developing a wide variety of functional hierarchical structures.

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Cite

BibTeXRIS
BibTeX
@article{yu2026batch,
  title = {{Batch sequential production of medicated Janus fibrous films of polyvinylpyrrolidone/shellac for treating pharyngitis}},
  author = {Xiaomin Yu and Yuxuan Xu and Bo Wang and Deng-Guang Yu and Ming Zhang and Yuanjie Zhu},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra08551b},
  url = {https://europepmc.org/article/PMC/PMC13674567},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Batch sequential production of medicated Janus fibrous films of polyvinylpyrrolidone/shellac for treating pharyngitis
AU  - Xiaomin Yu
AU  - Yuxuan Xu
AU  - Bo Wang
AU  - Deng-Guang Yu
AU  - Ming Zhang
AU  - Yuanjie Zhu
PY  - 2026
DA  - 2026/10/16
JO  - RSC advances
DO  - 10.1039/d6ra08551b
UR  - https://europepmc.org/article/PMC/PMC13674567
AB  - Janus structures are highly popular for developing functional materials, including drug delivery systems, whereas batch production of Janus fibrous films represents one of the most difficult challenges. Here, based on a brand-new integrated multi-orifice spinneret, Janus fibrous films were fabricated directly through a sequential batch electrospinning process. The films contained a top layer of polyvinylpyrrolidone (PVP), borneol, sucralose, and acetaminophen (APAP) for rapid drug release, and a bottom layer of shellac, PVP, borneol, sucralose, and APAP for sustained drug release. Scanning electron microscopy results verified that both the top and bottom layers were composed of ultra-thin linear fibers without beads or spindles. X-ray diffraction and Fourier-transform infrared spectroscopy results verified that borneol and APAP were present in the Janus films in an amorphous state and exhibited good compatibility with the polymeric matrices. The Janus fibrous films can be cut into small patches for topical administration to treat pharyngitis. Artificial tongue and saliva models were exploited to conduct in vitro dissolution tests. Biphasic release of the loaded APAP from the artificial tongue surface was demonstrated. The mechanism underlying the new technique-based process–structure–performance relationship was proposed. The reported protocols provide a brand-new approach for batch creating Janus fibrous films, which can be further exploited for developing a wide variety of functional hierarchical structures.
SN  - 2046-2069
ER  -