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Peer-reviewedCC BYScientific Reports

Hydrogenation of nitriles to primary amines by a phosphine-free cobalt(II) complex in the absence of H2 gas

  • Archana B1
  • Muthukumar Murugesan2
  • Sayon Ghosh1
  • Arup Sinha1
  • Siriyara Jagannatha Prathapa3
  1. 1Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology
  2. 2Department of Physics, School of Advanced Sciences, Vellore Institute of Technology
  3. 3Bruker India Scientific Pvt. Ltd
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Abstract

We report a well-defined Cobalt(II) complex supported by a tetradentate nitrogen-donor ligand, N,N-bis(pyridin-2-ylmethyl)quinolin-8-amine (BPMQA), which efficiently catalyzes the selective reduction of aromatic, heteroaromatic, aliphatic, and benzylic nitriles to the corresponding primary amines. Notably, the transformation proceeds without the need for external hydrogen gas or pressurized reaction conditions. The use of a non-pincer, phosphine-free ligand framework enables high catalytic efficiency at a low catalyst loading of 0.5 mol%, providing a practical and sustainable approach to nitrile hydrogenation without the requirement of hazardous high pressurized hydrogen gas.

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Cite

BibTeXRIS
BibTeX
@article{archana2026hydrogenation,
  title = {{Hydrogenation of nitriles to primary amines by a phosphine-free cobalt(II) complex in the absence of H2 gas}},
  author = {Archana B and Muthukumar Murugesan and Sayon Ghosh and Arup Sinha and Siriyara Jagannatha Prathapa},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-59196-1},
  url = {https://doi.org/10.1038/s41598-026-59196-1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Hydrogenation of nitriles to primary amines by a phosphine-free cobalt(II) complex in the absence of H2 gas
AU  - Archana B
AU  - Muthukumar Murugesan
AU  - Sayon Ghosh
AU  - Arup Sinha
AU  - Siriyara Jagannatha Prathapa
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-59196-1
UR  - https://doi.org/10.1038/s41598-026-59196-1
AB  - We report a well-defined Cobalt(II) complex supported by a tetradentate nitrogen-donor ligand, N,N-bis(pyridin-2-ylmethyl)quinolin-8-amine (BPMQA), which efficiently catalyzes the selective reduction of aromatic, heteroaromatic, aliphatic, and benzylic nitriles to the corresponding primary amines. Notably, the transformation proceeds without the need for external hydrogen gas or pressurized reaction conditions. The use of a non-pincer, phosphine-free ligand framework enables high catalytic efficiency at a low catalyst loading of 0.5 mol%, providing a practical and sustainable approach to nitrile hydrogenation without the requirement of hazardous high pressurized hydrogen gas.
SN  - 2045-2322
ER  -