Investigating the impact of allicin on periodontal tissue in rats with periodontitis associated with type 2 diabetes mellitus
- 1School of Stomatology, Xinjiang Medical University, Urumqi 830054, China
Abstract
Objective To investigate the effects of allicin on periodontal tissues in rats with type 2 diabetes mellitus (T2DM) and periodontitis. Methods Forty male SD rats were randomly divided into four groups (A-D), with 10 rats in each group. Group A was the healthy control group, with normal feeding and intragastric administration of normal saline. Group B was the diabetes periodontitis model group, with intragastric administration of normal saline. Groups C and D were diabetes periodontitis model groups treated with 30 and 60 mg/kg allicin, respectively, via intragastric administration. The rats were treated once daily for 4 weeks. During this period, the general condition of the rats was observed, and their fasting blood glucose levels were tracked. Before execution,the gingival index (GI), sulcus bleeding index (SBI), and probing depth (PD) were recorded. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, lactate dehydrogenase (LDH) in rat serum, and malondialdehyde (MDA) in periodontal tissue. Micro-CT scanning was used to assess the periodontal condition, and the distance from the amelocemental junction (CEJ) to the alveolar bone crest (ABC) (CEJ-ABC) was recorded. Periodontal tissue sections were stained with hematoxylin and eosin (HE) to observe pathological changes in periodontal tissue. Results In Group B, the levels of blood glucose, GI, SBI, PD, serum TNF-α, IL-6, LDH, MDA in periodontal tissues, CEJ-ABC, and inflammatory status shown by HE staining were all significantly higher than those in Group A (P< 0.05). The above indicators in Groups C and D were significantly lower than those in Group B, and Group D was significantly lower than Group C (P< 0.05). Conclusion Allicin can inhibit the progression of periodontitis in rats with type 2 diabetes by reducing blood glucose levels, levels of inflammation factors, and decreasing alveolar bone resorption.
Related
- Association Between the Severity of Periodontal Disease and Carotid Artery Pulsatility Index in Patients with Type 2 Diabetes Mellitus
- Concurrent Diabetes Mellitus and Periodontitis in U.S. Adults: Mortality Associations and Machine Learning Risk Prediction
- Oral Health Care Behaviors and Periodontal Disease Among Older Adults with Diabetes Mellitus in Northern Thailand.
- Systemic Glucose-Lowering Therapies and Periodontal and Peri-Implant Outcomes in Adults With Type 2 Diabetes Mellitus: A Systematic Review.
- Generative Artificial Intelligence in Periodontology: Application of OpenAI Models for the Classification of Periodontitis and Risk Assessment in Patients Undergoing Supportive Periodontal Care
BibTeX
@article{lijiapeng2026investigating,
title = {{Investigating the impact of allicin on periodontal tissue in rats with periodontitis associated with type 2 diabetes mellitus}},
author = {LI Jiapeng, SUN Jiaqi, NIGARE Yunusjiang, JIA Qianqian, ZULEINA Abula, GULINUER Awuti},
journal = {Kouqiang yixue},
year = {2026},
month = oct,
doi = {10.13591/j.cnki.kqyx.2026.10.009},
url = {https://doi.org/10.13591/j.cnki.kqyx.2026.10.009},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Investigating the impact of allicin on periodontal tissue in rats with periodontitis associated with type 2 diabetes mellitus
AU - LI Jiapeng, SUN Jiaqi, NIGARE Yunusjiang, JIA Qianqian, ZULEINA Abula, GULINUER Awuti
PY - 2026
DA - 2026/10/28
JO - Kouqiang yixue
DO - 10.13591/j.cnki.kqyx.2026.10.009
UR - https://doi.org/10.13591/j.cnki.kqyx.2026.10.009
AB - Objective To investigate the effects of allicin on periodontal tissues in rats with type 2 diabetes mellitus (T2DM) and periodontitis. Methods Forty male SD rats were randomly divided into four groups (A-D), with 10 rats in each group. Group A was the healthy control group, with normal feeding and intragastric administration of normal saline. Group B was the diabetes periodontitis model group, with intragastric administration of normal saline. Groups C and D were diabetes periodontitis model groups treated with 30 and 60 mg/kg allicin, respectively, via intragastric administration. The rats were treated once daily for 4 weeks. During this period, the general condition of the rats was observed, and their fasting blood glucose levels were tracked. Before execution,the gingival index (GI), sulcus bleeding index (SBI), and probing depth (PD) were recorded. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, lactate dehydrogenase (LDH) in rat serum, and malondialdehyde (MDA) in periodontal tissue. Micro-CT scanning was used to assess the periodontal condition, and the distance from the amelocemental junction (CEJ) to the alveolar bone crest (ABC) (CEJ-ABC) was recorded. Periodontal tissue sections were stained with hematoxylin and eosin (HE) to observe pathological changes in periodontal tissue. Results In Group B, the levels of blood glucose, GI, SBI, PD, serum TNF-α, IL-6, LDH, MDA in periodontal tissues, CEJ-ABC, and inflammatory status shown by HE staining were all significantly higher than those in Group A (P< 0.05). The above indicators in Groups C and D were significantly lower than those in Group B, and Group D was significantly lower than Group C (P< 0.05). Conclusion Allicin can inhibit the progression of periodontitis in rats with type 2 diabetes by reducing blood glucose levels, levels of inflammation factors, and decreasing alveolar bone resorption.
SN - 1003-9872
ER -