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Peer-reviewedCC BYScience Advances

PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy of KRAS -targeted therapy

  • Diogo Gonçalves1,2,3
  • Emma Guilbaud1,2,3,4
  • Léa Di Mascio1,2,3
  • Camille Guerrier1,2,3
  • Linda Mejri1,2,3
  • Sonia Núñez-Vázquez1,2,3
  • Lucie Levasseur1,2,3
  • Rachel Paul1,2,3
  • Corinne Menigot1,2
  • Christophe Bontoux5
  • Guylène Rignol3,6,7
  • Véronique Hofman3,6,7
7 more authors
  • Paul Hofman3,6,7
  • Marin Truchi3,8
  • Bernard Mari3,8
  • Laurent Yvan-Charvet1,3
  • Johanna Chiche1,2,3
  • Sandrine Marchetti1,2,3
  • Jean-Ehrland Ricci1,2,3
8 affiliations
  1. 1Université Côte d’Azur, INSERM, C3M, Nice, France.
  2. 2Équipe labellisée LIGUE Contre le Cancer, Nice, France.
  3. 3IHURespirERA, FHU OncoAge, Nice, France.
  4. 4Cancer Signaling and Microenvironment Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
  5. 5Department of Pathology, Cancer University Institute of Toulouse-Oncopole, University Hospital of Toulouse, 1 av Irène Joliot-Curie, Toulouse, 31059, France.
  6. 6Université Côte d’Azur, INSERM, CNRS, IRCAN, Nice, France.
  7. 7CHU de Nice, LPCE, Hospital-Integrated Biobank (BB-0033-00025), Nice, France.
  8. 8Université Côte d’Azur, CNRS, IPMC, Sophia-Antipolis, France.
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Cite

BibTeXRIS
BibTeX
@article{goncalves2026pink1mediated,
  title = {{PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy of KRAS -targeted therapy}},
  author = {Diogo Gonçalves and Emma Guilbaud and Léa Di Mascio and Camille Guerrier and Linda Mejri and Sonia Núñez-Vázquez and Lucie Levasseur and Rachel Paul and Corinne Menigot and Christophe Bontoux and Guylène Rignol and Véronique Hofman and Paul Hofman and Marin Truchi and Bernard Mari and Laurent Yvan-Charvet and Johanna Chiche and Sandrine Marchetti and Jean-Ehrland Ricci},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aef8820},
  url = {https://www.science.org/doi/10.1126/sciadv.aef8820},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - PINK1-mediated mitophagy supports lung cancer initiation and limits the efficacy of KRAS -targeted therapy
AU  - Diogo Gonçalves
AU  - Emma Guilbaud
AU  - Léa Di Mascio
AU  - Camille Guerrier
AU  - Linda Mejri
AU  - Sonia Núñez-Vázquez
AU  - Lucie Levasseur
AU  - Rachel Paul
AU  - Corinne Menigot
AU  - Christophe Bontoux
AU  - Guylène Rignol
AU  - Véronique Hofman
AU  - Paul Hofman
AU  - Marin Truchi
AU  - Bernard Mari
AU  - Laurent Yvan-Charvet
AU  - Johanna Chiche
AU  - Sandrine Marchetti
AU  - Jean-Ehrland Ricci
PY  - 2026
DA  - 2026/10/16
JO  - Science Advances
DO  - 10.1126/sciadv.aef8820
UR  - https://www.science.org/doi/10.1126/sciadv.aef8820
SN  - 2375-2548
ER  -