Research progress of mitophagy and its targeted therapeutic strategies in rheumatoid arthritis
- 1Shandong Medical and Pharmaceutical University Hospital
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease characterized by persistent joint inflammation and progressive bone destruction. In recent years, mitophagy—a selective form of autophagy—has garnered increasing attention. As a critical cellular process, mitophagy specifically removes damaged mitochondria and maintains mitochondrial homeostasis and energy metabolic balance. Accumulating evidence suggests that mitophagy not only regulates cell survival and metabolic reprogramming but also plays a central role in preserving immune homeostasis, modulating immune cell polarization, and suppressing inflammatory signaling. This article reviews the molecular mechanisms of mitophagy and its pivotal role in RA, along with recent advances in mitophagy-targeted therapeutic strategies, aiming to provide novel insights for RA treatment.
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BibTeX
@article{zhang2026research,
title = {{Research progress of mitophagy and its targeted therapeutic strategies in rheumatoid arthritis}},
author = {Yuanyuan Zhang and Fengmei Ge and Xuebin Wang},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1959419},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1959419/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Research progress of mitophagy and its targeted therapeutic strategies in rheumatoid arthritis
AU - Yuanyuan Zhang
AU - Fengmei Ge
AU - Xuebin Wang
PY - 2026
DA - 2026/10/15
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1959419
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1959419/full
AB - Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease characterized by persistent joint inflammation and progressive bone destruction. In recent years, mitophagy—a selective form of autophagy—has garnered increasing attention. As a critical cellular process, mitophagy specifically removes damaged mitochondria and maintains mitochondrial homeostasis and energy metabolic balance. Accumulating evidence suggests that mitophagy not only regulates cell survival and metabolic reprogramming but also plays a central role in preserving immune homeostasis, modulating immune cell polarization, and suppressing inflammatory signaling. This article reviews the molecular mechanisms of mitophagy and its pivotal role in RA, along with recent advances in mitophagy-targeted therapeutic strategies, aiming to provide novel insights for RA treatment.
SN - 1664-3224
ER -