Therapeutic potential of traditional Chinese medicine-derived formulations and extracts in
6 affiliations
- 1Department of Anesthesiology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518000, China; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China
- 2Department of Pharmacy, The First People's Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu, 610200, China
- 3Department of Clinical Laboratory, The First People's Hospital of Shuangliu District (West China Airport Hospital of Sichuan University), Chengdu, 610200, China
- 4Department of Clinical Laboratory, People's Hospital of Deyang City, Deyang, Sichuan, 618000, China
- 5Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China; Corresponding author.
- 6Department of Anesthesiology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518000, China; Corresponding author.
Abstract
Candida infections have emerged as a global public health crisis with elevating morbidity and mortality. Currently, the major obstacles to managing Candida infections are limited antifungal options, increasing fungal resistance, and serious adverse drug reactions, all of which significantly compromise patient prognosis. Consequently, developing innovative and effective therapeutic agents to address these challenges is exceedingly demanded. Accumulating evidence highlights that traditional Chinese medicines (TCMs) possess favorable antifungal properties, offering advantages such as improved efficacy, reduced resistance, and fewer side effects. As a result, TCMs are increasingly recognized as promising sources for discovering novel antifungals. In light of this, this review summarizes the relevant literature published over the last decade (2014–2024), providing an exhaustive overview of the anti- Candida effects of TCM-derived formulations and bioactive extracts, along with their underlying mechanisms. Collectively, we emphasize that future research trends in this field should focus on continuously identifying novel anti- Candida drugs derived from TCMs and elucidating their exact mechanisms of action. In addition, clinical trials should be conducted to validate the antifungal efficacy of TCMs in humans, ultimately advancing their future medical applications.
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BibTeX
@article{liu2026therapeutic,
title = {{Therapeutic potential of traditional Chinese medicine-derived formulations and extracts in}},
author = {Maozhu Liu and Cuilin He and Xiwen Wang and Jiao Ye and Enqiang Chen and Tao Tao},
journal = {Journal of Pharmaceutical Analysis},
year = {2026},
month = sep,
doi = {10.1016/j.jpha.2026.101549},
url = {https://doi.org/10.1016/j.jpha.2026.101549},
note = {CC BY},
}
RIS
TY - JOUR
TI - Therapeutic potential of traditional Chinese medicine-derived formulations and extracts in
AU - Maozhu Liu
AU - Cuilin He
AU - Xiwen Wang
AU - Jiao Ye
AU - Enqiang Chen
AU - Tao Tao
PY - 2026
DA - 2026/09/01
JO - Journal of Pharmaceutical Analysis
DO - 10.1016/j.jpha.2026.101549
UR - https://doi.org/10.1016/j.jpha.2026.101549
AB - Candida infections have emerged as a global public health crisis with elevating morbidity and mortality. Currently, the major obstacles to managing Candida infections are limited antifungal options, increasing fungal resistance, and serious adverse drug reactions, all of which significantly compromise patient prognosis. Consequently, developing innovative and effective therapeutic agents to address these challenges is exceedingly demanded. Accumulating evidence highlights that traditional Chinese medicines (TCMs) possess favorable antifungal properties, offering advantages such as improved efficacy, reduced resistance, and fewer side effects. As a result, TCMs are increasingly recognized as promising sources for discovering novel antifungals. In light of this, this review summarizes the relevant literature published over the last decade (2014–2024), providing an exhaustive overview of the anti- Candida effects of TCM-derived formulations and bioactive extracts, along with their underlying mechanisms. Collectively, we emphasize that future research trends in this field should focus on continuously identifying novel anti- Candida drugs derived from TCMs and elucidating their exact mechanisms of action. In addition, clinical trials should be conducted to validate the antifungal efficacy of TCMs in humans, ultimately advancing their future medical applications.
SN - 2095-1779
SN - 2214-0883
ER -