Design of redox-responsive fluorescent nanoceria via AIEgen-functionalized dextran for bioimaging
Abstract
In this study, we report the design and comprehensive physicochemical characterization of a redox-responsive nanoplatform based on cerium oxide nanoparticles (nanoceria) functionalized with thiolated dextran bearing aggregation-induced emission luminogens (AIEgens). The surface engineering strategy, involving covalent grafting via disulfide bonds, was meticulously validated using a multi-technique approach (FTIR, NMR, TGA, and TEM). We demonstrate that this functionalization successfully enhances the colloidal stability of nanoceria while preserving the fluorescence properties of the AIEgens. Furthermore, we evidence a redox-triggered detachment of the polymer shell in the presence of glutathione, mimicking intracellular conditions. This work provides a versatile and well-defined synthetic route to create stable, responsive, and fluorescent nanoceria, representing a significant step toward the development of advanced smart nanomaterials for biomedical applications.
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BibTeX
@article{chesneau2026design,
title = {{Design of redox-responsive fluorescent nanoceria via AIEgen-functionalized dextran for bioimaging}},
author = {Cléa Chesneau and Laurent Michely and Angélique Goffin and Eric Leroy and Sabrina Belbekhouche},
journal = {Results in Chemistry},
year = {2026},
month = oct,
doi = {10.1016/j.rechem.2026.103691},
url = {https://hal.science/hal-05837232v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Design of redox-responsive fluorescent nanoceria via AIEgen-functionalized dextran for bioimaging
AU - Cléa Chesneau
AU - Laurent Michely
AU - Angélique Goffin
AU - Eric Leroy
AU - Sabrina Belbekhouche
PY - 2026
DA - 2026/10/23
JO - Results in Chemistry
DO - 10.1016/j.rechem.2026.103691
UR - https://hal.science/hal-05837232v1
AB - In this study, we report the design and comprehensive physicochemical characterization of a redox-responsive nanoplatform based on cerium oxide nanoparticles (nanoceria) functionalized with thiolated dextran bearing aggregation-induced emission luminogens (AIEgens). The surface engineering strategy, involving covalent grafting via disulfide bonds, was meticulously validated using a multi-technique approach (FTIR, NMR, TGA, and TEM). We demonstrate that this functionalization successfully enhances the colloidal stability of nanoceria while preserving the fluorescence properties of the AIEgens. Furthermore, we evidence a redox-triggered detachment of the polymer shell in the presence of glutathione, mimicking intracellular conditions. This work provides a versatile and well-defined synthetic route to create stable, responsive, and fluorescent nanoceria, representing a significant step toward the development of advanced smart nanomaterials for biomedical applications.
SN - 2211-7156
ER -