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Peer-reviewedCC BY 4.0Chembiochem

Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery

  • Serife Dagdelen1,2
  • Paula D. Mestizo3
  • Marcin Mackiewicz4
  • Agnieszka Kurdyn5
  • Ewa Augustin5
  • Marcin Karbarz1,2
  • Felix Zelder3
5 affiliations
  1. 1Faculty of Chemistry University of Warsaw Warsaw Poland
  2. 2Biological and Chemical Research Center University of Warsaw Warsaw Poland
  3. 3Department of Chemistry University of Zürich Zürich Switzerland
  4. 4Department of Molecular Biology, Institute of Biochemistry, Faculty of Biology University of Warsaw Warsaw Poland
  5. 5Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry Gdańsk University of Technology Gdańsk Poland
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Abstract

Rapidly proliferating cancer cells display an elevated demand for vitamin B12, rendering this bacterial‐derived cofactor an attractive targeting motif for nanotherapeutic drug delivery. Herein, we report a concise two‐step synthesis of a polymerizable 5′‐modified vitamin B12 ‐monomer that enables the covalent integration of B12 into pH‐ and redox‐responsive nanogels. The resulting nanogels efficiently encapsulate doxorubicin through electrostatic interactions between the cationic drug and the anionic nanogel network, while enabling stimuli‐responsive drug release under tumor‐relevant conditions. In vitro studies revealed that DOX@B12‐nanogels retain potent antiproliferative activity against HT‐29 colorectal cancer cells (IC50 = 0.878 ± 0.102 μM), while decreasing cytotoxicity toward healthy CCD 841 CoN cells by 34‐fold relative to non‐B12‐functionalized control nanogels. These findings establish covalently engineered vitamin B12‐nanogels as a promising platform for selective and stimuli‐responsive anticancer drug delivery.

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Cite

BibTeXRIS
BibTeX
@article{dagdelen2026vitamin,
  title = {{Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery}},
  author = {Serife Dagdelen and Paula D. Mestizo and Marcin Mackiewicz and Agnieszka Kurdyn and Ewa Augustin and Marcin Karbarz and Felix Zelder},
  journal = {Chembiochem},
  year = {2026},
  month = oct,
  doi = {10.1002/cbic.70580},
  url = {https://doi.org/10.1002/cbic.70580},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Vitamin B12‐Functionalized Nanogels for pH‐, and Redox‐Responsive Doxorubicin Delivery
AU  - Serife Dagdelen
AU  - Paula D. Mestizo
AU  - Marcin Mackiewicz
AU  - Agnieszka Kurdyn
AU  - Ewa Augustin
AU  - Marcin Karbarz
AU  - Felix Zelder
PY  - 2026
DA  - 2026/10/01
JO  - Chembiochem
DO  - 10.1002/cbic.70580
UR  - https://doi.org/10.1002/cbic.70580
AB  - Rapidly proliferating cancer cells display an elevated demand for vitamin B12, rendering this bacterial‐derived cofactor an attractive targeting motif for nanotherapeutic drug delivery. Herein, we report a concise two‐step synthesis of a polymerizable 5′‐modified vitamin B12 ‐monomer that enables the covalent integration of B12 into pH‐ and redox‐responsive nanogels. The resulting nanogels efficiently encapsulate doxorubicin through electrostatic interactions between the cationic drug and the anionic nanogel network, while enabling stimuli‐responsive drug release under tumor‐relevant conditions. In vitro studies revealed that DOX@B12‐nanogels retain potent antiproliferative activity against HT‐29 colorectal cancer cells (IC50 = 0.878 ± 0.102 μM), while decreasing cytotoxicity toward healthy CCD 841 CoN cells by 34‐fold relative to non‐B12‐functionalized control nanogels. These findings establish covalently engineered vitamin B12‐nanogels as a promising platform for selective and stimuli‐responsive anticancer drug delivery.
SN  - 1439-4227
SN  - 1439-7633
ER  -