Effects of an orabase gel containing Libidibia ferrea extract on induced periodontitis in rats
Abstract
Introduction: Periodontitis is a chronic inflammatory disease associated with periodontal tissue destruction and bone loss. Libidibia ferrea presents antibacterial, anti-inflammatory and antioxidant properties with potential therapeutic relevance. Objective: To evaluate the therapeutic potential of an orabase gel containing L. ferrea extract in a rat model of experimental periodontitis. Methodology: Seventy animals were divided into seven groups: control, periodontitis (untreated), chlorhexidine, gel without L. ferrea, and L. ferrea gel at 2.5%, 5.0%, and 7.5%. After 20 days of treatment, the animals were euthanized, and periodontal parameters (gingival bleeding index, probing pocket depth, tooth mobility, alveolar bone loss, and myeloperoxidase activity), serum biochemical markers, oxidative stress markers in liver and kidney tissues, and histopathological changes were assessed. Results: Periodontitis induced significant periodontal and systemic alterations. L. ferrea gel produced dose-dependent improvements in periodontal parameters, with the 7.5% group showing reduced gingival bleeding, probing depth, and myeloperoxidase activity (p<0.05). Alveolar bone loss was attenuated mainly in lower concentrations. Triglycerides were significantly reduced in all treated groups (p<0.05). Renal markers showed partial improvement, with reduced urea and creatinine levels in treated animals. Oxidative stress markers indicated increased glutathione and reduced malondialdehyde in treated groups. Histology confirmed preservation of hepatic architecture and reduced steatosis, particularly in higher-dose and chlorhexidine groups. Conclusions: L. ferrea gel exhibits anti-inflammatory, antioxidant, and tissue-protective effects, suggesting its potential as an adjunctive therapy for periodontitis.
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BibTeX
@article{pessoa2026effects,
title = {{Effects of an orabase gel containing Libidibia ferrea extract on induced periodontitis in rats}},
author = {Larissa dos Santos Pessoa and Even Herlany Pereira Alves and Hávila Torres Araújo and Marcondes Cavalcante Santana Neto and Felipe Rodolfo Pereira da Silva and Paulo Roberto Carneiro Gomes and Ayslan Batista Barros and José Delano Barreto Marinho Filho and Ana Jersia Araújo and Daniel Fernando Pereira Vasconcelos},
journal = {Journal of Applied Oral Science},
year = {2026},
month = oct,
doi = {10.1590/1678-7765-2026-0608},
url = {https://doi.org/10.1590/1678-7765-2026-0608},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of an orabase gel containing Libidibia ferrea extract on induced periodontitis in rats
AU - Larissa dos Santos Pessoa
AU - Even Herlany Pereira Alves
AU - Hávila Torres Araújo
AU - Marcondes Cavalcante Santana Neto
AU - Felipe Rodolfo Pereira da Silva
AU - Paulo Roberto Carneiro Gomes
AU - Ayslan Batista Barros
AU - José Delano Barreto Marinho Filho
AU - Ana Jersia Araújo
AU - Daniel Fernando Pereira Vasconcelos
PY - 2026
DA - 2026/10/27
JO - Journal of Applied Oral Science
DO - 10.1590/1678-7765-2026-0608
UR - https://doi.org/10.1590/1678-7765-2026-0608
AB - Introduction: Periodontitis is a chronic inflammatory disease associated with periodontal tissue destruction and bone loss. Libidibia ferrea presents antibacterial, anti-inflammatory and antioxidant properties with potential therapeutic relevance. Objective: To evaluate the therapeutic potential of an orabase gel containing L. ferrea extract in a rat model of experimental periodontitis. Methodology: Seventy animals were divided into seven groups: control, periodontitis (untreated), chlorhexidine, gel without L. ferrea, and L. ferrea gel at 2.5%, 5.0%, and 7.5%. After 20 days of treatment, the animals were euthanized, and periodontal parameters (gingival bleeding index, probing pocket depth, tooth mobility, alveolar bone loss, and myeloperoxidase activity), serum biochemical markers, oxidative stress markers in liver and kidney tissues, and histopathological changes were assessed. Results: Periodontitis induced significant periodontal and systemic alterations. L. ferrea gel produced dose-dependent improvements in periodontal parameters, with the 7.5% group showing reduced gingival bleeding, probing depth, and myeloperoxidase activity (p<0.05). Alveolar bone loss was attenuated mainly in lower concentrations. Triglycerides were significantly reduced in all treated groups (p<0.05). Renal markers showed partial improvement, with reduced urea and creatinine levels in treated animals. Oxidative stress markers indicated increased glutathione and reduced malondialdehyde in treated groups. Histology confirmed preservation of hepatic architecture and reduced steatosis, particularly in higher-dose and chlorhexidine groups. Conclusions: L. ferrea gel exhibits anti-inflammatory, antioxidant, and tissue-protective effects, suggesting its potential as an adjunctive therapy for periodontitis.
SN - 1678-7765
SN - 1678-7757
ER -