Effects of DPP4 Inhibition on Inflammation and Oxidative Stress in Experimental Gestational Diabetes Mellitus
- 1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Selcuk University, 42130 Konya, Turkey
Abstract
Gestational diabetes mellitus (GDM) is a common pregnancy complication, with inflammation and oxidative stress playing a significant role in its pathogenesis. Therefore, this study evaluated the effects of vildagliptin on metabolic, hormonal, inflammatory, and oxidative stress parameters in an STZ-induced GDM model. Rats were divided into five groups: control, GDM, GDM + V10, GDM + V20 and GDM + V30. High blood glucose levels were observed in the GDM group, while a slight decrease was observed in the vildagliptin groups. While GLP-1 levels decreased in the GDM group, they increased in the GDM + V20 and GDM + V30 groups. Overall, an increase in pro-inflammatory cytokines and a decrease in anti-inflammatory cytokines were observed in the GDM group, while vildagliptin administration reversed these effects. Among the vildagliptin groups, IL-10 was found to be lowest and IL-6 highest in the GDM + V20 group. Although fluctuations were generally observed in oxidative stress markers, the highest MDA levels and the lowest GSH levels were found in the GDM + V20 group. In the GDM group, FW and PE were lower, and PW was higher. In contrast, FW and PE were higher, and PW was lower in the GDM + V30 group than in the GDM group. The best results were obtained at a dose of 30 mg/kg; however, further research is needed to confirm this effect.
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BibTeX
@article{akarslan2026effects,
title = {{Effects of DPP4 Inhibition on Inflammation and Oxidative Stress in Experimental Gestational Diabetes Mellitus}},
author = {Öznur Tufan Akarslan and Ayşe Er},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27188303},
url = {https://www.mdpi.com/1422-0067/27/18/8303},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Effects of DPP4 Inhibition on Inflammation and Oxidative Stress in Experimental Gestational Diabetes Mellitus
AU - Öznur Tufan Akarslan
AU - Ayşe Er
PY - 2026
DA - 2026/09/18
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27188303
UR - https://www.mdpi.com/1422-0067/27/18/8303
AB - Gestational diabetes mellitus (GDM) is a common pregnancy complication, with inflammation and oxidative stress playing a significant role in its pathogenesis. Therefore, this study evaluated the effects of vildagliptin on metabolic, hormonal, inflammatory, and oxidative stress parameters in an STZ-induced GDM model. Rats were divided into five groups: control, GDM, GDM + V10, GDM + V20 and GDM + V30. High blood glucose levels were observed in the GDM group, while a slight decrease was observed in the vildagliptin groups. While GLP-1 levels decreased in the GDM group, they increased in the GDM + V20 and GDM + V30 groups. Overall, an increase in pro-inflammatory cytokines and a decrease in anti-inflammatory cytokines were observed in the GDM group, while vildagliptin administration reversed these effects. Among the vildagliptin groups, IL-10 was found to be lowest and IL-6 highest in the GDM + V20 group. Although fluctuations were generally observed in oxidative stress markers, the highest MDA levels and the lowest GSH levels were found in the GDM + V20 group. In the GDM group, FW and PE were lower, and PW was higher. In contrast, FW and PE were higher, and PW was lower in the GDM + V30 group than in the GDM group. The best results were obtained at a dose of 30 mg/kg; however, further research is needed to confirm this effect.
SN - 1422-0067
ER -