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Peer-reviewedCC BY-NCDermatology practical & conceptual

Mortality in Patients with Acquired Perforating Dermatosis: Results from the First Multicenter Case-Control Study.

  • Sebastián Reyes-García1
  • Francisco Vázquez-López1,2
  • Cristina Galache-Osuna1,2
  • Blanca Vivanco-Allende3,2
  • Carmen González-Vela4
  • Jorge Santos-Juanes1,2
  • Marcos A González-López5
5 affiliations
  1. 1Dermatology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain.
  2. 2Dermatology Department, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain.
  3. 3Pathology Department, Hospital Universitario Central de Asturias, University of Oviedo, Asturias, Spain.
  4. 4Pathology Department, Hospital Universitario Marqués de Valdecilla, Cantabria, Spain.
  5. 5GRIDER - Dermatology Investigation Group of Asturias, University of Oviedo, Asturias, Spain.
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Abstract

Introduction

Mortality data in patients with acquired perforating dermatosis (APD) are limited.Objectives

To assess, for the first time, the risk of all-cause mortality in adult patients with APD and to explore associated systemic comorbidities.Methods

This retrospective multicenter case-control study included adult patients diagnosed with APD and age-, sex-, and year-matched controls. We evaluated overall survival and the prevalence of seven major comorbidities: systemic malignancy, chronic obstructive pulmonary disease (COPD), severe liver disease, diabetes mellitus, arterial disease, hypertension, and dyslipidemia. Statistical analyses included univariate comparisons (Fisher's exact test and logistic regression), Kaplan-Meier survival estimates with log-rank tests, and multivariate Cox proportional hazards models.Results

Fifty-one patients with APD and 102 controls (1:2 ratio) were finally included in this investigation. Patients with APD had a significantly increased risk of mortality compared to controls ( log-rank test, P<0.001). In the multivariate Cox regression analysis, arterial disease emerged as the sole independent predictor of mortality (adjusted hazard ratio [HR]:7.716; 95% confidence interval [CI]: 2.774-21.464; P<0.001).Conclusions

This is the first study to identify a potential association between APD and increased allcause mortality, primarily driven by coexisting arterial disease. These findings highlight the importance of comprehensive management in APD patients and emphasize the dermatologist's role in multidisciplinary care aimed at improving long-term outcomes.

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Cite

BibTeXRIS
BibTeX
@article{reyesgarcia2026mortality,
  title = {{Mortality in Patients with Acquired Perforating Dermatosis: Results from the First Multicenter Case-Control Study.}},
  author = {Sebastián Reyes-García and Francisco Vázquez-López and Cristina Galache-Osuna and Blanca Vivanco-Allende and Carmen González-Vela and Jorge Santos-Juanes and Marcos A González-López},
  journal = {Dermatology practical \& conceptual},
  year = {2026},
  month = jul,
  doi = {10.5826/dpc.1603a6672},
  url = {https://europepmc.org/article/MED/42858395},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Mortality in Patients with Acquired Perforating Dermatosis: Results from the First Multicenter Case-Control Study.
AU  - Sebastián Reyes-García
AU  - Francisco Vázquez-López
AU  - Cristina Galache-Osuna
AU  - Blanca Vivanco-Allende
AU  - Carmen González-Vela
AU  - Jorge Santos-Juanes
AU  - Marcos A González-López
PY  - 2026
DA  - 2026/07/31
JO  - Dermatology practical & conceptual
DO  - 10.5826/dpc.1603a6672
UR  - https://europepmc.org/article/MED/42858395
AB  - Introduction  Mortality data in patients with acquired perforating dermatosis (APD) are limited.Objectives  To assess, for the first time, the risk of all-cause mortality in adult patients with APD and to explore associated systemic comorbidities.Methods  This retrospective multicenter case-control study included adult patients diagnosed with APD and age-, sex-, and year-matched controls. We evaluated overall survival and the prevalence of seven major comorbidities: systemic malignancy, chronic obstructive pulmonary disease (COPD), severe liver disease, diabetes mellitus, arterial disease, hypertension, and dyslipidemia. Statistical analyses included univariate comparisons (Fisher's exact test and logistic regression), Kaplan-Meier survival estimates with log-rank tests, and multivariate Cox proportional hazards models.Results  Fifty-one patients with APD and 102 controls (1:2 ratio) were finally included in this investigation. Patients with APD had a significantly increased risk of mortality compared to controls ( log-rank test, P<0.001). In the multivariate Cox regression analysis, arterial disease emerged as the sole independent predictor of mortality (adjusted hazard ratio [HR]:7.716; 95% confidence interval [CI]: 2.774-21.464; P<0.001).Conclusions  This is the first study to identify a potential association between APD and increased allcause mortality, primarily driven by coexisting arterial disease. These findings highlight the importance of comprehensive management in APD patients and emphasize the dermatologist's role in multidisciplinary care aimed at improving long-term outcomes.
SN  - 2160-9381
ER  -