Through the Long COVID Looking-Glass: An Unremitting Conundrum of Mitochondria?
- 1Institute of Cell Biophysics, Russian Academy of Sciences, Federal Research Center, Moscow Region, Puschino 142290, Russia
- 2Institute of Future Biophysics, Moscow Center for Advanced Studies, Moscow 123592, Russia
- 3National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician V.I. Kulakov, Moscow 117997, Russia
Abstract
Plentiful data indicate a high post-COVID risk of developing pathologies that are long-term and result from disruption of multiple cellular processes. The significance of this data becomes increasingly clear as it links the pandemic’s effects to enduring health problems which could affect millions. These conditions are usually caused by different problems with mitochondria. These problems can include less efficient energy production and increased removal of damaged cells, showing how complex cell health is. Having other health problems such as high blood pressure, type 2 diabetes, brain diseases, and cancer related to renin–angiotensin–aldosterone system (RAAS) imbalance worsened COVID-19 and its lasting effects. This highlights the importance of focused treatments for these at-risk groups. This review seeks to evaluate the information on this issue, carefully studying the features and symptoms often associated with mitochondrial disorders. What happens next in the pandemic is still to be seen, but we know there is much to learn. It is important to lessen the effects of the pandemic on people with comorbidities as much as possible.
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BibTeX
@article{kononova2026through,
title = {{Through the Long COVID Looking-Glass: An Unremitting Conundrum of Mitochondria?}},
author = {Svetlana Kononova and Natalia Bobkova and Sergey Leonov and Gennadiy Sukhikh},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27219753},
url = {https://www.mdpi.com/1422-0067/27/21/9753},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Through the Long COVID Looking-Glass: An Unremitting Conundrum of Mitochondria?
AU - Svetlana Kononova
AU - Natalia Bobkova
AU - Sergey Leonov
AU - Gennadiy Sukhikh
PY - 2026
DA - 2026/10/30
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219753
UR - https://www.mdpi.com/1422-0067/27/21/9753
AB - Plentiful data indicate a high post-COVID risk of developing pathologies that are long-term and result from disruption of multiple cellular processes. The significance of this data becomes increasingly clear as it links the pandemic’s effects to enduring health problems which could affect millions. These conditions are usually caused by different problems with mitochondria. These problems can include less efficient energy production and increased removal of damaged cells, showing how complex cell health is. Having other health problems such as high blood pressure, type 2 diabetes, brain diseases, and cancer related to renin–angiotensin–aldosterone system (RAAS) imbalance worsened COVID-19 and its lasting effects. This highlights the importance of focused treatments for these at-risk groups. This review seeks to evaluate the information on this issue, carefully studying the features and symptoms often associated with mitochondrial disorders. What happens next in the pandemic is still to be seen, but we know there is much to learn. It is important to lessen the effects of the pandemic on people with comorbidities as much as possible.
SN - 1422-0067
ER -