Skin-Protective Effects of Marinophyll, a Carotenoid From Marine Erythrobacter sp. SDW2.
4 affiliations
- 1COSMAX BTI R&I Center, Seongnamsi, South Korea.
- 2Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.
- 3Center For Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
- 4School of Environmental Engineering, University of Seoul, Seoul, South Korea.
Abstract
Background
Previous studies have highlighted that marine organisms, such as microalgae and marine bacteria, exhibit significantly higher and more sustainable biosynthetic yields of unique carotenoids compared to terrestrial sources. These advantages in production efficiency have sparked significant interest in developing materials derived from marine origins. Marinophyll, natural carotenoids extracted from marine sources, have demonstrated potential in managing oxidative stress and inflammation linked to various skin conditions.Materials and methods
HaCaT keratinocytes were treated with various concentrations of Marinophyll and hydrogen peroxide (H₂O₂) to assess cell viability and intracellular ROS production. Antioxidant enzyme expression, including Nrf2, HO-1, and SOD2, was evaluated using RT-PCR and immunocytochemistry. The anti-inflammatory effects of Marinophyll were investigated in HaCaT cells treated with IL-4 and Poly I:C, and skin barrier repair was assessed in human skin explants using immunofluorescence staining. The skin explants were obtained from healthy adult donors (aged 43-57 years) undergoing elective breast reduction or abdominoplasty surgery, with informed consent and approval from the relevant ethics committee. All tissues were provided by Seoul National University Bundang Hospital.Results
The results showed that Marinophyll reduced intracellular ROS production in H₂O₂-exposed HaCaT cells. Additionally, Marinophyll significantly upregulated the mRNA and protein expression of Nrf2, HO-1, and SOD2 in HaCaT cells. Pretreatment with Marinophyll reduced the levels of inflammatory cytokines IL-1α and IL-1β induced by IL-4 and Poly I:C. In human skin explants, Marinophyll enhanced filaggrin expression, contributing to improved skin barrier function.Conclusion
Marinophyll demonstrates significant antioxidant, anti-inflammatory, and skin barrier-enhancing properties, making it a promising candidate for therapeutic applications in managing oxidative stress and inflammation-associated skin disorders.
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BibTeX
@article{kim2026skinprotective,
title = {{Skin-Protective Effects of Marinophyll, a Carotenoid From Marine Erythrobacter sp. SDW2.}},
author = {Hyeyoun Kim and Seoyeon Kyung and Kyung Eun Lee and Youn-Hwa Nho and Jeoungjin Ryu and Minsun Park and Yong Jun Choi and Seunghyun Kang},
journal = {Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)},
year = {2026},
month = oct,
doi = {10.1111/srt.70404},
url = {https://europepmc.org/article/MED/42960918},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Skin-Protective Effects of Marinophyll, a Carotenoid From Marine Erythrobacter sp. SDW2.
AU - Hyeyoun Kim
AU - Seoyeon Kyung
AU - Kyung Eun Lee
AU - Youn-Hwa Nho
AU - Jeoungjin Ryu
AU - Minsun Park
AU - Yong Jun Choi
AU - Seunghyun Kang
PY - 2026
DA - 2026/10/30
JO - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
DO - 10.1111/srt.70404
UR - https://europepmc.org/article/MED/42960918
AB - Background Previous studies have highlighted that marine organisms, such as microalgae and marine bacteria, exhibit significantly higher and more sustainable biosynthetic yields of unique carotenoids compared to terrestrial sources. These advantages in production efficiency have sparked significant interest in developing materials derived from marine origins. Marinophyll, natural carotenoids extracted from marine sources, have demonstrated potential in managing oxidative stress and inflammation linked to various skin conditions.Materials and methods HaCaT keratinocytes were treated with various concentrations of Marinophyll and hydrogen peroxide (H₂O₂) to assess cell viability and intracellular ROS production. Antioxidant enzyme expression, including Nrf2, HO-1, and SOD2, was evaluated using RT-PCR and immunocytochemistry. The anti-inflammatory effects of Marinophyll were investigated in HaCaT cells treated with IL-4 and Poly I:C, and skin barrier repair was assessed in human skin explants using immunofluorescence staining. The skin explants were obtained from healthy adult donors (aged 43-57 years) undergoing elective breast reduction or abdominoplasty surgery, with informed consent and approval from the relevant ethics committee. All tissues were provided by Seoul National University Bundang Hospital.Results The results showed that Marinophyll reduced intracellular ROS production in H₂O₂-exposed HaCaT cells. Additionally, Marinophyll significantly upregulated the mRNA and protein expression of Nrf2, HO-1, and SOD2 in HaCaT cells. Pretreatment with Marinophyll reduced the levels of inflammatory cytokines IL-1α and IL-1β induced by IL-4 and Poly I:C. In human skin explants, Marinophyll enhanced filaggrin expression, contributing to improved skin barrier function.Conclusion Marinophyll demonstrates significant antioxidant, anti-inflammatory, and skin barrier-enhancing properties, making it a promising candidate for therapeutic applications in managing oxidative stress and inflammation-associated skin disorders.
SN - 0909-752X
SN - 1600-0846
ER -