Protective and Reparative Effects of Naematelia aurantialba Ethanol Extract Against UV-Induced Skin Photoaging and Its Underlying Mechanisms
Abstract
This study aimed to investigate the protective effects of Naematelia aurantialba ethanol extract (NAAE) against skin photoaging. Furthermore, we sought to elucidate the underlying repair mechanisms and related pathways. The results indicated that NAAE treatment significantly enhanced cell viability and proliferation under UV stress, while exerting potent antioxidant effects by effectively reducing intracellular reactive oxygen species (ROS) accumulation and mitigating oxidative damage. Furthermore, NAAE accelerated the migration capacity of damaged cells and promoted skin repair. In animal models, NAAE inhibited UV-induced skin injuries in a concentration-dependent manner and facilitated tissue regeneration. Further investigations revealed that NAAE exerted photoprotective effects by modulating several key metabolic pathways and biological processes, including fatty acid metabolism and nuclear receptor activity. Moreover, NAAE positively influenced the skin microbiota by reducing the abundance of harmful bacteria and promoting the proliferation of beneficial bacteria, potentially enhancing skin barrier function through the cross-system mechanism of the "gut-skin axis." This study provides a theoretical basis for the use of NAAE in preventing and repairing skin photoaging and offers new insights for the development of natural plant-derived skincare products.
Related
- Multi-omics identifies PCK1-associated immunometabolic regulation underlying the protective effects of sinomenine in vascular dementia
- Protective effects and underlying mechanisms of naringenin in myocardial ischemia/reperfusion injury: a systematic review and preclinical meta-analysis
- Sustaining microglial reparative function enhances stroke recovery
- Multi-Omics Integration Reveals Macrophage Lysosomal Remodeling as a Signature of Reparative Immunity in Human Lung Ischemia-Reperfusion Injury
- Identification of a Novel Placental Peptide with Skin Reparative Properties by Cell-Surface Affinity Screening.
BibTeX
@article{peng2026protective,
title = {{Protective and Reparative Effects of Naematelia aurantialba Ethanol Extract Against UV-Induced Skin Photoaging and Its Underlying Mechanisms}},
author = {Guanjie Peng and Bowen Sun and Sihui Chen and Lanyue Zhang and Yiyan Zeng and Zhenhai Huang and Qingqing Liu},
journal = {Journal of Oleo Science},
year = {2026},
month = aug,
doi = {10.5650/jos.ess26048},
url = {https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess26048/_article},
note = {CC BY},
}
RIS
TY - JOUR
TI - Protective and Reparative Effects of Naematelia aurantialba Ethanol Extract Against UV-Induced Skin Photoaging and Its Underlying Mechanisms
AU - Guanjie Peng
AU - Bowen Sun
AU - Sihui Chen
AU - Lanyue Zhang
AU - Yiyan Zeng
AU - Zhenhai Huang
AU - Qingqing Liu
PY - 2026
DA - 2026/08/01
JO - Journal of Oleo Science
DO - 10.5650/jos.ess26048
UR - https://www.jstage.jst.go.jp/article/jos/75/8/75_jos.ess26048/_article
AB - This study aimed to investigate the protective effects of Naematelia aurantialba ethanol extract (NAAE) against skin photoaging. Furthermore, we sought to elucidate the underlying repair mechanisms and related pathways. The results indicated that NAAE treatment significantly enhanced cell viability and proliferation under UV stress, while exerting potent antioxidant effects by effectively reducing intracellular reactive oxygen species (ROS) accumulation and mitigating oxidative damage. Furthermore, NAAE accelerated the migration capacity of damaged cells and promoted skin repair. In animal models, NAAE inhibited UV-induced skin injuries in a concentration-dependent manner and facilitated tissue regeneration. Further investigations revealed that NAAE exerted photoprotective effects by modulating several key metabolic pathways and biological processes, including fatty acid metabolism and nuclear receptor activity. Moreover, NAAE positively influenced the skin microbiota by reducing the abundance of harmful bacteria and promoting the proliferation of beneficial bacteria, potentially enhancing skin barrier function through the cross-system mechanism of the "gut-skin axis." This study provides a theoretical basis for the use of NAAE in preventing and repairing skin photoaging and offers new insights for the development of natural plant-derived skincare products.
SN - 1347-3352
SN - 1345-8957
ER -