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Peer-reviewedCC BY 4.0PLOS One

Tragopogon coelesyriacus Boiss. attenuates ethanol-induced gastric ulcer in vivo: modulation of oxidative stress, inflammation, and apoptosis

  • Hanan Ibrahim Alsharif1
  • Mohammad Khaled Abu-Sini2
  • Abdulrahman Ismael3
  • Naz Farhad Abdulqadir4
  • Gharieb S. El-Sayyad5
  • Ahmed A.J. Jabbar6
  • Sara Basil Abu Jalboush7
  • Rawan Fahad Mosallam Almehmadi
  • Talal Salem Al-Qaisi
  • Khalid M. Alqaisi
7 affiliations
  1. 1Department of Chemistry, College of Science, University of Jeddah, Jeddah, Saudi Arabia
  2. 2Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan
  3. 3Department of Community Health Nursing, Cihan University-Erbil, Erbil, Iraq
  4. 4Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq
  5. 5Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
  6. 6Department of Medical and Clinical Laboratory Technology, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan
  7. 7Department of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates
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Abstract

Tragopogon coelesyriacus is a traditional herbal medicine used for gastrointestinal disorders, mediated by its phytoconstituents. This study explores acute toxicity and gastroprotective potency of methanolic extracts of Tragopogon coelesyriacus (METC) in rats. Rats were aligned in 5 groups and pretreated with either normal saline, lansoprazole, or METC (200 and 400 mg/kg) before 5 mL/kg ethanol-induced gastric ulceration. The two-week toxicity study for METC (2 and 5 g/kg) showed no physiological alterations, behavioral changes, or morbidity in rats. Pretreatment with METC (200 and 400 mg/kg) improved gastric defense factors (mucus secretion and total stomach acidity), limiting mucosal penetrations and the lesioned areas. The histopathological results showed that METC (200 and 400 mg/kg) suppressed ethanol-induced gastric tissue alterations, indicated by increased gastric protective percentages (51.02% and 65.67%), less submucosal edema, epithelial exfoliation, lower mucous metaplasia, and necrotic areas. METC supplementation (200 and 400 mg/kg) restored the level of superoxide dismutase and catalase, while reducing the MDA by 29.84% and 48.64%, respectively. This was parallel with the anti-inflammatory effects of METC (200 and 400 mg/kg), decreasing TNF-α by 34.59%, 47.36%; IL-6 by 24.95%, 30.32%, and increasing IL-10 by 73.94%, 179.92%, respectively, relative to ulcer controls. Additionally, METC (200 and 400 mg/kg) remarkably modulated apoptotic proteins, lowering Bax by 31.10% and 45.50%, and increasing HSP 70 by 28.12 and 65.5%, respectively. The outcomes highlight the significant gastroprotective potential of Tragopogon coelesyriacus, which was mainly associated with its antioxidant, anti-inflammatory, and anti-apoptosis properties, making it a viable source for gastric ulcer management.

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Cite

BibTeXRIS
BibTeX
@article{alsharif2026tragopogon,
  title = {{Tragopogon coelesyriacus Boiss. attenuates ethanol-induced gastric ulcer in vivo: modulation of oxidative stress, inflammation, and apoptosis}},
  author = {Hanan Ibrahim Alsharif and Mohammad Khaled Abu-Sini and Abdulrahman Ismael and Naz Farhad Abdulqadir and Gharieb S. El-Sayyad and Ahmed A.J. Jabbar and Sara Basil Abu Jalboush and Rawan Fahad Mosallam Almehmadi and Talal Salem Al-Qaisi and Khalid M. Alqaisi},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0355381},
  url = {https://doi.org/10.1371/journal.pone.0355381},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Tragopogon coelesyriacus Boiss. attenuates ethanol-induced gastric ulcer in vivo: modulation of oxidative stress, inflammation, and apoptosis
AU  - Hanan Ibrahim Alsharif
AU  - Mohammad Khaled Abu-Sini
AU  - Abdulrahman Ismael
AU  - Naz Farhad Abdulqadir
AU  - Gharieb S. El-Sayyad
AU  - Ahmed A.J. Jabbar
AU  - Sara Basil Abu Jalboush
AU  - Rawan Fahad Mosallam Almehmadi
AU  - Talal Salem Al-Qaisi
AU  - Khalid M. Alqaisi
PY  - 2026
DA  - 2026/09/16
JO  - PLOS One
DO  - 10.1371/journal.pone.0355381
UR  - https://doi.org/10.1371/journal.pone.0355381
AB  - Tragopogon coelesyriacus is a traditional herbal medicine used for gastrointestinal disorders, mediated by its phytoconstituents. This study explores acute toxicity and gastroprotective potency of methanolic extracts of Tragopogon coelesyriacus (METC) in rats. Rats were aligned in 5 groups and pretreated with either normal saline, lansoprazole, or METC (200 and 400 mg/kg) before 5 mL/kg ethanol-induced gastric ulceration. The two-week toxicity study for METC (2 and 5 g/kg) showed no physiological alterations, behavioral changes, or morbidity in rats. Pretreatment with METC (200 and 400 mg/kg) improved gastric defense factors (mucus secretion and total stomach acidity), limiting mucosal penetrations and the lesioned areas. The histopathological results showed that METC (200 and 400 mg/kg) suppressed ethanol-induced gastric tissue alterations, indicated by increased gastric protective percentages (51.02% and 65.67%), less submucosal edema, epithelial exfoliation, lower mucous metaplasia, and necrotic areas. METC supplementation (200 and 400 mg/kg) restored the level of superoxide dismutase and catalase, while reducing the MDA by 29.84% and 48.64%, respectively. This was parallel with the anti-inflammatory effects of METC (200 and 400 mg/kg), decreasing TNF-α by 34.59%, 47.36%; IL-6 by 24.95%, 30.32%, and increasing IL-10 by 73.94%, 179.92%, respectively, relative to ulcer controls. Additionally, METC (200 and 400 mg/kg) remarkably modulated apoptotic proteins, lowering Bax by 31.10% and 45.50%, and increasing HSP 70 by 28.12 and 65.5%, respectively. The outcomes highlight the significant gastroprotective potential of Tragopogon coelesyriacus, which was mainly associated with its antioxidant, anti-inflammatory, and anti-apoptosis properties, making it a viable source for gastric ulcer management.
SN  - 1932-6203
ER  -