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PreprintCC BY-NCbioRxiv

The claustrum encodes and scales appetitive feeding

  • C. de Almeida
  • N. Mashhour
  • B. Bertrand
  • A. Ansoult
  • J. Castel
  • S. Luquet
  • G. Gangarossa1
  1. 1Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, F-75013 Paris, France
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Abstract

The claustrum regulates reward processing, but its role in feeding remains unknown. We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.

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Cite

BibTeXRIS
BibTeX
@misc{almeida2026claustrum,
  title = {{The claustrum encodes and scales appetitive feeding}},
  author = {C. de Almeida and N. Mashhour and B. Bertrand and A. Ansoult and J. Castel and S. Luquet and G. Gangarossa},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.21.753287},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.21.753287v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - The claustrum encodes and scales appetitive feeding
AU  - C. de Almeida
AU  - N. Mashhour
AU  - B. Bertrand
AU  - A. Ansoult
AU  - J. Castel
AU  - S. Luquet
AU  - G. Gangarossa
PY  - 2026
DA  - 2026/09/21
PB  - bioRxiv
DO  - 10.64898/2026.09.21.753287
UR  - https://www.biorxiv.org/content/10.64898/2026.09.21.753287v1
AB  - The claustrum regulates reward processing, but its role in feeding remains unknown. We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.
ER  -