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Peer-reviewedCC BY-NC 4.0Neuropsychopharmacology

The claustrum encodes and scales appetitive feeding

  • Camille de Almeida
  • Nejmeh Mashhour
  • Benoit Bertrand
  • Anthony Ansoult
  • Julien Castel
  • Serge Luquet
  • Giuseppe Gangarossa
Open at sourcePDFDOICite

Abstract

The claustrum regulates reward processing, but its role in feeding remains unknown.

We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.

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Cite

BibTeXRIS
BibTeX
@article{almeida2026claustrum,
  title = {{The claustrum encodes and scales appetitive feeding}},
  author = {Camille de Almeida and Nejmeh Mashhour and Benoit Bertrand and Anthony Ansoult and Julien Castel and Serge Luquet and Giuseppe Gangarossa},
  journal = {Neuropsychopharmacology},
  year = {2026},
  month = oct,
  doi = {10.1038/s41386-026-02573-1},
  url = {https://hal.science/hal-05785989v1},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - The claustrum encodes and scales appetitive feeding
AU  - Camille de Almeida
AU  - Nejmeh Mashhour
AU  - Benoit Bertrand
AU  - Anthony Ansoult
AU  - Julien Castel
AU  - Serge Luquet
AU  - Giuseppe Gangarossa
PY  - 2026
DA  - 2026/10/05
JO  - Neuropsychopharmacology
DO  - 10.1038/s41386-026-02573-1
UR  - https://hal.science/hal-05785989v1
AB  - The claustrum regulates reward processing, but its role in feeding remains unknown.  We report that palatable food recruits claustral neurons and a claustrum-to-medial prefrontal cortex circuit whose activation reduces high-fat diet intake. These findings identify the claustrum as a key regulator of appetitive feeding, with potential implications for metabopsychiatric disorders.  .
SN  - 0893-133X
SN  - 0007-0920
ER  -