Omicron respiratory threat in renal transplant recipients.
4 affiliations
- 1Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
- 2Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
- 3Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
- 4Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Abstract
Background
Omicron was identified as one of the worrisome strains of corona virus. Renal transplant recipients (RTRs) are classified as high-risk groups due to immunosuppressed conditions. Thus, this study was conducted with the aim of comparing these patients infected with the Omicron variant with the general population infected with this variant compare.Methods
62 RTRs infected with the Omicron strain and 60 patients with non-RTRs who were hospitalized from 2021 to 2022 at the peak of Omicron in Tehran, Shiraz and Babol, Iran were included in the study. The two groups were compared regarding clinical findings, laboratory results, pulmonary manifestations on high-resolution computed tomography (HRCT), and adverse effects.Results
In both groups the most common respiratory symptoms were similar. The ground glass opacity was the most frequent finding on CT scan and was seen in 86 cases (70.5%). There was a reduced absolute lymphocyte count (ALC) and platelet count (85.4% and 41.9%, respectively) in RTRs and the rise of creatinine levels was more in RTRs than those in non-RTRs (79% versus 31.6%). the disease severity (16.1% versus 5%, P = 0.008) and adverse outcomes, such as mechanical ventilation (MV) (12.9% versus 0%, P = 0.004), and the mortality rate was significantly higher in RTRs than the general population.Conclusion
There was no significant difference in clinical symptoms between two groups except diarrhea. MV, ICU admission and mortality were significantly higher in RTRs under prolonged immunosuppression.
Related
- Relevance of Seasonal Revaccination against Respiratory Syncytial Virus in Hematology Patients: First Insights in Stem Cell Transplant Recipients
- Renal Transplantation in Recipients With Modified Lower Urinary Tract: A Systematic Review and Implications for Adult Transplant Practice
- Diagnostic Performance of 99mTc-MAG3 Renal Scintigraphy for Acute Tubular Necrosis and Acute Rejection in Kidney Transplant Recipients with Suspected Graft Dysfunction During the First 90 Days: A Single-Center, Biopsy-Referenced Retrospective Study
- Calcineurin Inhibitors and Male Fertility in Renal Transplant Recipients: A Comprehensive Review of Molecular Pathomechanisms and Reproductive Toxicity of Cyclosporine A and Tacrolimus.
- Neutrophil Gelatinase-associated Lipocalin and Interleukin-8 as a Predictor of Graft Dysfunction in Live-donor Renal Transplant Recipients
BibTeX
@article{akbari2026omicron,
title = {{Omicron respiratory threat in renal transplant recipients.}},
author = {Roghayeh Akbari and Sara Abolghasemi and Mojtaba Shafiekhani and Masoumeh Asgharpour and Zahra Zare and Hamed Nikoupour and Jamshid Roozbeh and Elmira Mahmoudi Chalmiani and Farshid Oliaie and Mana Baziboroun and Shiva Nezami},
journal = {Caspian journal of internal medicine},
year = {2026},
month = sep,
doi = {10.22088/cjim.17.3.642},
url = {https://europepmc.org/article/MED/42924299},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Omicron respiratory threat in renal transplant recipients.
AU - Roghayeh Akbari
AU - Sara Abolghasemi
AU - Mojtaba Shafiekhani
AU - Masoumeh Asgharpour
AU - Zahra Zare
AU - Hamed Nikoupour
AU - Jamshid Roozbeh
AU - Elmira Mahmoudi Chalmiani
AU - Farshid Oliaie
AU - Mana Baziboroun
AU - Shiva Nezami
PY - 2026
DA - 2026/09/01
JO - Caspian journal of internal medicine
DO - 10.22088/cjim.17.3.642
UR - https://europepmc.org/article/MED/42924299
AB - Background Omicron was identified as one of the worrisome strains of corona virus. Renal transplant recipients (RTRs) are classified as high-risk groups due to immunosuppressed conditions. Thus, this study was conducted with the aim of comparing these patients infected with the Omicron variant with the general population infected with this variant compare.Methods 62 RTRs infected with the Omicron strain and 60 patients with non-RTRs who were hospitalized from 2021 to 2022 at the peak of Omicron in Tehran, Shiraz and Babol, Iran were included in the study. The two groups were compared regarding clinical findings, laboratory results, pulmonary manifestations on high-resolution computed tomography (HRCT), and adverse effects.Results In both groups the most common respiratory symptoms were similar. The ground glass opacity was the most frequent finding on CT scan and was seen in 86 cases (70.5%). There was a reduced absolute lymphocyte count (ALC) and platelet count (85.4% and 41.9%, respectively) in RTRs and the rise of creatinine levels was more in RTRs than those in non-RTRs (79% versus 31.6%). the disease severity (16.1% versus 5%, P = 0.008) and adverse outcomes, such as mechanical ventilation (MV) (12.9% versus 0%, P = 0.004), and the mortality rate was significantly higher in RTRs than the general population.Conclusion There was no significant difference in clinical symptoms between two groups except diarrhea. MV, ICU admission and mortality were significantly higher in RTRs under prolonged immunosuppression.
SN - 2008-6164
SN - 2008-6172
ER -