Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 19 min ago
Peer-reviewedCC BYResearch (Washington, D.C.)

Positioning Creation of Cell Communication Channels via Chinese Microneedle.

  • Yiwen Xu1,2,3,4,5,6
  • Miaojie Fang1,2,3,4,5,6
  • Zhenzhong Chen1,2,3,4,5,6
  • Hong Liu1,2,3,4,5,6
  • Yucheng Xue1,2,3,4,5,6
  • Zilong Li1,2,3,4,5,6
  • Yue Lin1,2,3,4,5,6
  • Kelei Wang1,2,3,4,5,6
  • Feng Lin1,2,3,4,5,6
  • Ning Zhang1,2,3,4,5,6
6 affiliations
  1. 1Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  2. 2Orthopedics Research Institute, Zhejiang University, Hangzhou, Zhejiang, China.
  3. 3Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
  4. 4Zhejiang Provincial Clinical Medical Research Center for Motor System Diseases, Hangzhou, Zhejiang, China.
  5. 5International Chinese Musculoskeletal Research Society, Hangzhou, Zhejiang, China.
  6. 6State Key Laboratory of Transvascular Implantation Devices, Hangzhou, Zhejiang, China.
Read full textPDFDOICite

Abstract

The core dilemma of senescence mitigation lies in the disrupted and even detrimental communication between senescent cells and local immune cells. Existing delivery methods cannot precisely establish protective intercellular communication channels across cell types within the enclosed lesion cavity. In this study, we utilize Chinese microneedle technology for precise, minimally invasive localization of aged lesions, and to release spatially targeted and temporally sustained dual-field to create intercellular communication channels between macrophages and senescent cells. The unique physical properties of this Chinese microneedle system confine the current path to specific spatiotemporal windows, releasing an electro-field while simultaneously activating dynamic van der Waals forces that release functionalized hydrogel microparticles, thereby superimposing a vita-field. Within the dual-field active zone, the electro-field not only attenuates cellular senescence but also forms a communication channel from senescent cells to macrophages, driving macrophages into a hyperactivated state. Meanwhile, the vita-field stabilizes the macrophage membrane, enabling long-term, stable communication between hyperactivated macrophages and senescent cells. Ultimately, the intercellular communication channels established by this Chinese microneedle system alleviate cellular senescence and apoptosis, supporting the repair of aged lesions.

Related

  1. Calibrating trust in generative artificial intelligence for clinical communication through Chinese medical humanism
    Jiarui Han, Sifan Chen, Mengyu Li +3
    Frontiers in Public HealthPeer-reviewedCC BY 4.0Epidemiology & public healthCrossref
  2. Traditional Chinese medicine interventions and mitochondrial communication in myocardial and cerebral ischemia: a critical review
    Zhijie Wan, Xinyue Wang, Ziqiong Xu +2
    Frontiers in PharmacologyPeer-reviewedCC BY 4.0Pharmacology & toxicologyFrontiersCrossref
  3. Optimizing physician-patient communication through an integrated perspective of prospect theory and the ultimatum game: a controlled study among patients undergoing elective surgery or invasive procedures in a Chinese tertiary hospital
    Muqing Niu, Panpan Liu
    Frontiers in Public HealthPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefPMC
  4. A smart photothermal microneedle system for dual-targeted therapy of osteoarthritis via MMPs inhibition
    Yuxuan Hou, Wen Niu, Wenpin Qin +12
    Nature CommunicationsPeer-reviewedCC BY-NC-ND 4.0Full textGeneral medicineCrossref
  5. Composite microneedle-mediated co-delivery of magnesium hydride–magnolol for androgenetic alopecia
    Wenting Wang, Xiaoxia Wang, Xiaojiang Hou +4
    RSC advancesPeer-reviewedCC BYFull textPharmacology & toxicologyEurope PMCDOAJPMC

Cite

BibTeXRIS
BibTeX
@article{xu2026positioning,
  title = {{Positioning Creation of Cell Communication Channels via Chinese Microneedle.}},
  author = {Yiwen Xu and Miaojie Fang and Zhenzhong Chen and Hong Liu and Yucheng Xue and Zilong Li and Yue Lin and Kelei Wang and Feng Lin and Ning Zhang},
  journal = {Research (Washington, D.C.)},
  year = {2026},
  month = oct,
  doi = {10.34133/research.1459},
  url = {https://europepmc.org/article/MED/42947963},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Positioning Creation of Cell Communication Channels via Chinese Microneedle.
AU  - Yiwen Xu
AU  - Miaojie Fang
AU  - Zhenzhong Chen
AU  - Hong Liu
AU  - Yucheng Xue
AU  - Zilong Li
AU  - Yue Lin
AU  - Kelei Wang
AU  - Feng Lin
AU  - Ning Zhang
PY  - 2026
DA  - 2026/10/27
JO  - Research (Washington, D.C.)
DO  - 10.34133/research.1459
UR  - https://europepmc.org/article/MED/42947963
AB  - The core dilemma of senescence mitigation lies in the disrupted and even detrimental communication between senescent cells and local immune cells. Existing delivery methods cannot precisely establish protective intercellular communication channels across cell types within the enclosed lesion cavity. In this study, we utilize Chinese microneedle technology for precise, minimally invasive localization of aged lesions, and to release spatially targeted and temporally sustained dual-field to create intercellular communication channels between macrophages and senescent cells. The unique physical properties of this Chinese microneedle system confine the current path to specific spatiotemporal windows, releasing an electro-field while simultaneously activating dynamic van der Waals forces that release functionalized hydrogel microparticles, thereby superimposing a vita-field. Within the dual-field active zone, the electro-field not only attenuates cellular senescence but also forms a communication channel from senescent cells to macrophages, driving macrophages into a hyperactivated state. Meanwhile, the vita-field stabilizes the macrophage membrane, enabling long-term, stable communication between hyperactivated macrophages and senescent cells. Ultimately, the intercellular communication channels established by this Chinese microneedle system alleviate cellular senescence and apoptosis, supporting the repair of aged lesions.
SN  - 2639-5274
ER  -