Skip to content
DraconiticResearch
Search Sources API
186,631 studies31 sourcesUpdated 50 min ago
Peer-reviewedCC BY 4.0Frontiers in Cardiovascular Medicine

Crosstalk mechanisms, clinical correlations and therapeutic implications linking OSA with HFpEF progression

  • Weitong Zhao1,2
  • Jianchang Xie2
  • Tao Lyu2
  • Yigang Zhong2
  1. 1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University
  2. 2Department of Cardiology, Affiliated Hangzhou First People’s Hospital, Westlake University School of Medicine
Open at sourceDOICite

Abstract

Obstructive sleep apnea (OSA) is closely associated with and represents a potential biological contributor to the onset and progression of heart failure with preserved ejection fraction (HFpEF). Although abundant studies have clarified the associations of OSA with cardiovascular diseases including hypertension, coronary artery disease, arrhythmia and heart failure with reduced ejection fraction (HFrEF), the exact pathophysiological mechanisms underlying OSA-related HFpEF remain poorly elucidated, and relevant systematic reviews are still scarce. This review summarizes the pathophysiological links and clinical correlations between OSA and HFpEF. Beyond classical mechanisms such as intrathoracic pressure swings and sympathetic overactivation, we highlight the pivotal roles of systemic inflammation, obesity, vascular injury and metabolic dysfunction in disease progression. We further elaborate how these interactive pathological pathways shape a clinically identifiable OSA–HFpEF phenotype, and summarize phenotype-based diagnostic strategies. Moreover, we discuss therapeutic implications for targeted management for patients with isolated OSA and comorbid OSA-HFpEF. Finally, we outline existing limitations and future research perspectives in the mechanistic exploration, diagnosis and management of OSA-HFpEF comorbidity.

Related

  1. Gut Microbiota-Driven Neuroimmune Crosstalk in Ulcerative Colitis: From Mechanisms to Therapeutic Implications
    Lihan Yu, Lei He, Yanjun Lu
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. Liver-spleen axis: Deciphering a crucial crosstalk in non-alcoholic fatty liver disease progression and therapeutic implications
    Giovanni Tarantino, Vincenzo Citro
    World Journal of GastroenterologyPeer-reviewedCC BY-NC16 citedEpidemiology & public healthOpenAlex
  3. Bidirectional cellular senescence crosstalk in MASLD: mechanisms, disease progression, and treatment strategies
    Jinchao Shi, Changpu Zhao, Lei Luo +8
    Frontiers in EndocrinologyPeer-reviewedCC BY 4.0Endocrinology & metabolismCrossref
  4. Airway epithelial cell–lung macrophage crosstalk in type 2-high and low asthma endotypes: mechanisms and therapeutic strategies
    Yinuo Wang, Yuxuan Sun, Suning Mu +3
    Frontiers in ImmunologyPeer-reviewedCC BY 4.0PhysiologyCrossref
  5. Microbiome-Immune Crosstalk in Inflammatory Skin Diseases: Mechanisms and Therapeutic Potential of Probiotics.
    Pranvi Sharma, Tanaka Nhokwara, Jaswinder Singh +2
    Immunity, inflammation and diseasePeer-reviewedCC BYFull textGeneral medicineEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{zhao2026crosstalk,
  title = {{Crosstalk mechanisms, clinical correlations and therapeutic implications linking OSA with HFpEF progression}},
  author = {Weitong Zhao and Jianchang Xie and Tao Lyu and Yigang Zhong},
  journal = {Frontiers in Cardiovascular Medicine},
  year = {2026},
  month = nov,
  doi = {10.3389/fcvm.2026.1879690},
  url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1879690/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Crosstalk mechanisms, clinical correlations and therapeutic implications linking OSA with HFpEF progression
AU  - Weitong Zhao
AU  - Jianchang Xie
AU  - Tao Lyu
AU  - Yigang Zhong
PY  - 2026
DA  - 2026/11/03
JO  - Frontiers in Cardiovascular Medicine
DO  - 10.3389/fcvm.2026.1879690
UR  - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1879690/full
AB  - Obstructive sleep apnea (OSA) is closely associated with and represents a potential biological contributor to the onset and progression of heart failure with preserved ejection fraction (HFpEF). Although abundant studies have clarified the associations of OSA with cardiovascular diseases including hypertension, coronary artery disease, arrhythmia and heart failure with reduced ejection fraction (HFrEF), the exact pathophysiological mechanisms underlying OSA-related HFpEF remain poorly elucidated, and relevant systematic reviews are still scarce. This review summarizes the pathophysiological links and clinical correlations between OSA and HFpEF. Beyond classical mechanisms such as intrathoracic pressure swings and sympathetic overactivation, we highlight the pivotal roles of systemic inflammation, obesity, vascular injury and metabolic dysfunction in disease progression. We further elaborate how these interactive pathological pathways shape a clinically identifiable OSA–HFpEF phenotype, and summarize phenotype-based diagnostic strategies. Moreover, we discuss therapeutic implications for targeted management for patients with isolated OSA and comorbid OSA-HFpEF. Finally, we outline existing limitations and future research perspectives in the mechanistic exploration, diagnosis and management of OSA-HFpEF comorbidity.
SN  - 2297-055X
ER  -