Dynamic control of cell state transitions during tissue morphogenesis
- 1Biophysical Mechanisms of Morphogenesis Lab, Cluster of Excellence Physics of Life (PoL), TU Dresden, Dresden, Germany
Abstract
Morphogenesis, the process by which cells, tissues, and organs acquire and maintain their form, is essential for embryogenesis, regeneration, and disease progression. During morphogenesis, cells within tissues dynamically interact with biophysical and biochemical signals from their environment by modifying their shape, gene expression, and function. These modifications often lead to transitions between cell states, and with that, to the establishment of functional programs that will in turn define embryonic stages or tissue states. Here, we discuss how the interplay of gene expression programs, chromatin modifications, and biophysical factors from the microenvironment contributes to the robust coordination of morphogenesis by allowing cells within tissues to dynamically transit across functional stages.
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BibTeX
@article{saraiva2026dynamic,
title = {{Dynamic control of cell state transitions during tissue morphogenesis}},
author = {Joana E Saraiva and Sandra Edwards-Jorquera and Elias H Barriga},
journal = {The EMBO Journal},
year = {2026},
month = sep,
doi = {10.1038/s44318-026-00905-x},
url = {https://doi.org/10.1038/s44318-026-00905-x},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Dynamic control of cell state transitions during tissue morphogenesis
AU - Joana E Saraiva
AU - Sandra Edwards-Jorquera
AU - Elias H Barriga
PY - 2026
DA - 2026/09/04
JO - The EMBO Journal
DO - 10.1038/s44318-026-00905-x
UR - https://doi.org/10.1038/s44318-026-00905-x
AB - Morphogenesis, the process by which cells, tissues, and organs acquire and maintain their form, is essential for embryogenesis, regeneration, and disease progression. During morphogenesis, cells within tissues dynamically interact with biophysical and biochemical signals from their environment by modifying their shape, gene expression, and function. These modifications often lead to transitions between cell states, and with that, to the establishment of functional programs that will in turn define embryonic stages or tissue states. Here, we discuss how the interplay of gene expression programs, chromatin modifications, and biophysical factors from the microenvironment contributes to the robust coordination of morphogenesis by allowing cells within tissues to dynamically transit across functional stages.
SN - 0261-4189
SN - 1460-2075
ER -