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Peer-reviewedLicence not statedScience

Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor

  • Zoe L. Grant1
  • Shuzhen Kuang1
  • Shu Zhang2,1
  • Abraham Horrillo1,3
  • Zhe Chen1
  • Kavitha S. Rao1
  • Cemre Celen1
  • Vasumathi Kameswaran1
  • Carine Joubran4,1
  • Pik Ki Lau5,6
  • Keyi Dong5,6
  • Bing Yang5,6
7 more authors
  • Weronika M. Bartosik5,6
  • Nathan R. Zemke5,6
  • Bing Ren5,6
  • Deepak Srivastava7,1,8
  • Irfan S. Kathiriya9
  • Katherine S. Pollard10,11,1
  • Benoit G. Bruneau12,1,8
12 affiliations
  1. 1Gladstone Institutes, San Francisco, CA, USA
  2. 2Bioinformatics Graduate Program, University of California, San Francisco, CA, USA
  3. 3TETRAD Graduate Program, University of California, San Francisco, CA, USA
  4. 4Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA, USA
  5. 5Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA, USA
  6. 6Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA
  7. 7Department of Pediatrics and Biochemistry, University of California, San Francisco, CA, USA
  8. 8Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA, USA
  9. 9Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA
  10. 10Chan Zuckerberg Biohub, San Francisco, CA, USA
  11. 11Department of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA
  12. 12Department of Pediatrics, Cardiovascular Research Institute, Institute for Human Genetics, and the Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA
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Cite

BibTeXRIS
BibTeX
@article{grant2026dosedependent,
  title = {{Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor}},
  author = {Zoe L. Grant and Shuzhen Kuang and Shu Zhang and Abraham Horrillo and Zhe Chen and Kavitha S. Rao and Cemre Celen and Vasumathi Kameswaran and Carine Joubran and Pik Ki Lau and Keyi Dong and Bing Yang and Weronika M. Bartosik and Nathan R. Zemke and Bing Ren and Deepak Srivastava and Irfan S. Kathiriya and Katherine S. Pollard and Benoit G. Bruneau},
  journal = {Science},
  year = {2026},
  month = jul,
  doi = {10.1126/science.adv5434},
  url = {https://doi.org/10.1101/2025.01.09.632202},
}
RIS
TY  - JOUR
TI  - Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor
AU  - Zoe L. Grant
AU  - Shuzhen Kuang
AU  - Shu Zhang
AU  - Abraham Horrillo
AU  - Zhe Chen
AU  - Kavitha S. Rao
AU  - Cemre Celen
AU  - Vasumathi Kameswaran
AU  - Carine Joubran
AU  - Pik Ki Lau
AU  - Keyi Dong
AU  - Bing Yang
AU  - Weronika M. Bartosik
AU  - Nathan R. Zemke
AU  - Bing Ren
AU  - Deepak Srivastava
AU  - Irfan S. Kathiriya
AU  - Katherine S. Pollard
AU  - Benoit G. Bruneau
PY  - 2026
DA  - 2026/07/23
JO  - Science
DO  - 10.1126/science.adv5434
UR  - https://doi.org/10.1101/2025.01.09.632202
SN  - 0036-8075
SN  - 0193-4511
SN  - 1095-9203
ER  -