Skip to content
DraconiticResearch
Search Sources API
181,713 studies31 sourcesUpdated 2 min ago
Peer-reviewedLicence not statedNature

De novo design of miniproteins targeting GPCRs

  • Edin Muratspahić1,2
  • David Feldman3,4,5
  • David E. Kim4,6,5
  • Xiangli Qu4,5
  • Ana-Maria Bratovianu3,7
  • Paula Rivera-Sánchez3,7
  • Jan Hendrik Voss7
  • Emil Peter Thrane Hertz7
  • Mads Gravers Jeppesen7
  • Federica Dimitri3
  • Kensuke Sakamoto8,9
  • Amrita Nallathambi7
60 more authors
  • Pia Peceli7
  • Jianjun Cao10,11
  • Brian P. Cary10,11
  • Matthew J. Belousoff10,11
  • Peter Keov10,11
  • Phuc N. H. Trinh10,11
  • Qingchao Chen12
  • Yue Ren12
  • Justyn Fine13,14
  • Sudha Mishra15
  • Annu Dalal15
  • Shachie Sinha15
  • Ramanuj Banerjee15
  • Manisankar Ganguly15
  • Karthik Varappalayam Karuppusamy16
  • Isaac Sappington4,5
  • Thomas Schlichthaerle4,5
  • Jason Z. Zhang4,5
  • Arvind Pillai4,5
  • Brian Coventry4,5
  • Ljubica Mihaljević4,6,5
  • Magnus S. Bauer4,5
  • Susana Vázquez Torres4,5
  • Amir Motmaen4,5
  • Gyu Rie Lee4,6,5
  • Long Tran17,5
  • Xinru Wang4,5
  • Inna Goreshnik4,5
  • Dionne K. Vafeados4,5
  • Justin E. Svendsen18,19
  • Parisa Hosseinzadeh18,19
  • Nicolai Lindegaard20
  • Matthäus Brandt20
  • Yann Waltenspühl20
  • Kristine Deibler20
  • Lukas Deweid20
  • Anja Bennett20
  • Jendrik Schöppe20
  • Tiantang Dong21
  • Xiaoli Yan21
  • Luke T. Oostdyk22
  • William Cao22
  • Lakshmi Anantharaman22
  • Johan Juhl Weisser23
  • Jesper F. Bastlund23
  • Christoffer Bundgaard23
  • Ayodeji A. Asuni23
  • Justin G. English4,5

60 listed; 72 in total.

23 affiliations
  1. 1Department of Biochemistry, University of Washington, Seattle, WA, USA. [email protected]
  2. 2Institute for Protein Design, University of Washington, Seattle, WA, USA. [email protected]
  3. 3BioInnovation Institute, Copenhagen, Denmark
  4. 4Department of Biochemistry, University of Washington, Seattle, WA, USA
  5. 5Institute for Protein Design, University of Washington, Seattle, WA, USA
  6. 6Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA
  7. 7Skape Bio, Copenhagen, Denmark
  8. 8Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  9. 9NIMH Psychoactive Drug Screening Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
  10. 10ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
  11. 11Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
  12. 12MRC Laboratory of Molecular Biology, Cambridge, UK
  13. 13Program in Molecular Biophysics, Johns Hopkins University, Baltimore, MD, USA
  14. 14Translational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA
  15. 15Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India
  16. 16Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
  17. 17Department of Chemical Engineering, University of Washington, Seattle, WA, USA
  18. 18Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA
  19. 19Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR, USA
  20. 20Novo Nordisk, Måløv, Denmark
  21. 21Novo Nordisk Research Centre China, Beijing, China
  22. 22LeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA
  23. 23Global Research, H. Lundbeck, Copenhagen, Denmark
Open at sourcePDFDOICite

Related

  1. Computational De Novo Design of Miniprotein Candidate Neutralizers Targeting the IL-23 Cytokine Subunit p19
    Raghav Paladugu, Fardina Fathmiul Alam
    arXivPreprintCC BY 4.0Full textBiophysicsarXiv
  2. De novo Rubisco design with protein language models
    A. J. Kehl, S. K. S. Chu, J. H. Pereira +6
    bioRxivPreprintAll rights reservedFull textMolecular biology & gene regulationbioRxiv
  3. Aptamers without SELEX: De novo design from protein structure in hours
    Vladislava A. Dolgusheva, Iosif V. Leibin, Natalia O. Kudryashova +14
    Molecular therapy. Nucleic acidsPeer-reviewedCC BY-NC-NDFull textMolecular biology & gene regulationEurope PMC
  4. De novo design of miniprotein inhibitors of bacterial adhesins
    Adam M. Chazin-Gray, Tuscan R. Thompson, Edward D. B. Lopatto +27
    Nature CommunicationsPeer-reviewedCC BY-NC-ND 4.0Full textMolecular biology & gene regulationCrossref
  5. De novo design of allosterically controlled enzymes
    A. Shida, K. Wang, H. Choi +10
    bioRxivPreprintCC BYFull text1 citedMolecular biology & gene regulationbioRxiv

Cite

BibTeXRIS
BibTeX
@article{muratspahic2026novo,
  title = {{De novo design of miniproteins targeting GPCRs}},
  author = {Edin Muratspahić and David Feldman and David E. Kim and Xiangli Qu and Ana-Maria Bratovianu and Paula Rivera-Sánchez and Jan Hendrik Voss and Emil Peter Thrane Hertz and Mads Gravers Jeppesen and Federica Dimitri and Kensuke Sakamoto and Amrita Nallathambi and Pia Peceli and Jianjun Cao and Brian P. Cary and Matthew J. Belousoff and Peter Keov and Phuc N. H. Trinh and Qingchao Chen and Yue Ren and Justyn Fine and Sudha Mishra and Annu Dalal and Shachie Sinha and Ramanuj Banerjee and Manisankar Ganguly and Karthik Varappalayam Karuppusamy and Isaac Sappington and Thomas Schlichthaerle and Jason Z. Zhang and Arvind Pillai and Brian Coventry and Ljubica Mihaljević and Magnus S. Bauer and Susana Vázquez Torres and Amir Motmaen and Gyu Rie Lee and Long Tran and Xinru Wang and Inna Goreshnik and Dionne K. Vafeados and Justin E. Svendsen and Parisa Hosseinzadeh and Nicolai Lindegaard and Matthäus Brandt and Yann Waltenspühl and Kristine Deibler and Lukas Deweid and Anja Bennett and Jendrik Schöppe and Tiantang Dong and Xiaoli Yan and Luke T. Oostdyk and William Cao and Lakshmi Anantharaman and Johan Juhl Weisser and Jesper F. Bastlund and Christoffer Bundgaard and Ayodeji A. Asuni and Justin G. English},
  journal = {Nature},
  year = {2026},
  month = may,
  doi = {10.1038/s41586-026-10656-8},
  url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC13692778/},
}
RIS
TY  - JOUR
TI  - De novo design of miniproteins targeting GPCRs
AU  - Edin Muratspahić
AU  - David Feldman
AU  - David E. Kim
AU  - Xiangli Qu
AU  - Ana-Maria Bratovianu
AU  - Paula Rivera-Sánchez
AU  - Jan Hendrik Voss
AU  - Emil Peter Thrane Hertz
AU  - Mads Gravers Jeppesen
AU  - Federica Dimitri
AU  - Kensuke Sakamoto
AU  - Amrita Nallathambi
AU  - Pia Peceli
AU  - Jianjun Cao
AU  - Brian P. Cary
AU  - Matthew J. Belousoff
AU  - Peter Keov
AU  - Phuc N. H. Trinh
AU  - Qingchao Chen
AU  - Yue Ren
AU  - Justyn Fine
AU  - Sudha Mishra
AU  - Annu Dalal
AU  - Shachie Sinha
AU  - Ramanuj Banerjee
AU  - Manisankar Ganguly
AU  - Karthik Varappalayam Karuppusamy
AU  - Isaac Sappington
AU  - Thomas Schlichthaerle
AU  - Jason Z. Zhang
AU  - Arvind Pillai
AU  - Brian Coventry
AU  - Ljubica Mihaljević
AU  - Magnus S. Bauer
AU  - Susana Vázquez Torres
AU  - Amir Motmaen
AU  - Gyu Rie Lee
AU  - Long Tran
AU  - Xinru Wang
AU  - Inna Goreshnik
AU  - Dionne K. Vafeados
AU  - Justin E. Svendsen
AU  - Parisa Hosseinzadeh
AU  - Nicolai Lindegaard
AU  - Matthäus Brandt
AU  - Yann Waltenspühl
AU  - Kristine Deibler
AU  - Lukas Deweid
AU  - Anja Bennett
AU  - Jendrik Schöppe
AU  - Tiantang Dong
AU  - Xiaoli Yan
AU  - Luke T. Oostdyk
AU  - William Cao
AU  - Lakshmi Anantharaman
AU  - Johan Juhl Weisser
AU  - Jesper F. Bastlund
AU  - Christoffer Bundgaard
AU  - Ayodeji A. Asuni
AU  - Justin G. English
PY  - 2026
DA  - 2026/05/21
JO  - Nature
DO  - 10.1038/s41586-026-10656-8
UR  - https://pmc.ncbi.nlm.nih.gov/articles/PMC13692778/
SN  - 0028-0836
SN  - 1476-4687
ER  -