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Peer-reviewedCC BYCase reports in radiology

Case Report: Uncommon MRI and PET/CT Imaging Findings in a Rare Case of Vertebral Sarcoidosis.

  • Waqas Hassoon Hammadi Hammadi1
  • Melpomeni Varvounis2
  • Konstantina Foufa3
  1. 1Department of Radiology Aarhus University Hospital Aarhus Denmark auh.dk.
  2. 2Danish Hospital for Rheumatic Diseases Sønderborg Denmark.
  3. 3Department of Radiology Lillebaelt Hospital Kolding Denmark sygehuslillebaelt.dk.
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Abstract

Sarcoidosis is a systemic inflammatory granulomatous disease that can affect almost any body organ. Among the musculoskeletal manifestations, which are uncommon, vertebral sarcoidosis is extremely rare, while depicting a significant variability in radiological features. We present a unique case of a 52-year-old male, who was referred for MRI of the lumbar spine due to inflammatory back pain. Disc bulging at the intervertebral spaces L1/L2, L4/L5, and L5/S1 was found, without any signs of spinal stenosis or nerve root involvement. In addition, multiple small focal lesions were noticed in the vertebrae and the iliac bones, thus raising suspicion of bone metastases. Subsequent 18F-FDG PET/CT showed neither evidence of primary tumor nor abnormal uptake in the vertebral lesions. No lytic or sclerotic pattern was recognized in CT scanning. Eventually, vertebral sarcoidosis was histologically confirmed by a nontargeted bone marrow biopsy of the iliac crest, performed as part of a standard hematological work-up, which is the diagnostic gold standard for this pathologic entity. Follow-up of the lesions with MRI scans showed stability over time, despite therapy with methotrexate.

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Cite

BibTeXRIS
BibTeX
@article{hammadi2026case,
  title = {{Case Report: Uncommon MRI and PET/CT Imaging Findings in a Rare Case of Vertebral Sarcoidosis.}},
  author = {Waqas Hassoon Hammadi Hammadi and Melpomeni Varvounis and Konstantina Foufa},
  journal = {Case reports in radiology},
  year = {2026},
  month = nov,
  doi = {10.1155/crra/1056186},
  url = {https://europepmc.org/article/MED/42996778},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Case Report: Uncommon MRI and PET/CT Imaging Findings in a Rare Case of Vertebral Sarcoidosis.
AU  - Waqas Hassoon Hammadi Hammadi
AU  - Melpomeni Varvounis
AU  - Konstantina Foufa
PY  - 2026
DA  - 2026/11/05
JO  - Case reports in radiology
DO  - 10.1155/crra/1056186
UR  - https://europepmc.org/article/MED/42996778
AB  - Sarcoidosis is a systemic inflammatory granulomatous disease that can affect almost any body organ. Among the musculoskeletal manifestations, which are uncommon, vertebral sarcoidosis is extremely rare, while depicting a significant variability in radiological features. We present a unique case of a 52-year-old male, who was referred for MRI of the lumbar spine due to inflammatory back pain. Disc bulging at the intervertebral spaces L1/L2, L4/L5, and L5/S1 was found, without any signs of spinal stenosis or nerve root involvement. In addition, multiple small focal lesions were noticed in the vertebrae and the iliac bones, thus raising suspicion of bone metastases. Subsequent 18F-FDG PET/CT showed neither evidence of primary tumor nor abnormal uptake in the vertebral lesions. No lytic or sclerotic pattern was recognized in CT scanning. Eventually, vertebral sarcoidosis was histologically confirmed by a nontargeted bone marrow biopsy of the iliac crest, performed as part of a standard hematological work-up, which is the diagnostic gold standard for this pathologic entity. Follow-up of the lesions with MRI scans showed stability over time, despite therapy with methotrexate.
SN  - 2090-6862
SN  - 2090-6870
ER  -