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Peer-reviewedCC BY 4.0Biomolecules

Association of Inflammatory Biomarkers with Child–Pugh and MELD Scores in Alcohol-Related Cirrhosis

  • Luciana-Florentina Vasile1
  • Mihaela Ionescu2
  • Victor-Mihai Sacerdotianu3
  • Petrică Popa3
  • Sergiu Marian Cazacu3
  • Bogdan Silviu Ungureanu3
  • Ioan-Alexandru Văcariu1
  • Alexandru-Valentin Popescu1
  • Carmen-Daniela Neagoe4
4 affiliations
  1. 1Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
  2. 2Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
  3. 3Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
  4. 4Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
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Abstract

Background: Cirrhosis is characterized by persistent systemic inflammation and immune dysregulation, both contributing to disease progression and poor clinical outcomes. Readily available inflammatory biomarkers have been proposed as complementary tools for disease severity assessment; however, data in alcohol-related cirrhosis remain limited. This study aimed to evaluate the association between inflammatory markers and established severity scores in patients with alcohol-related cirrhosis. Methods: This prospective cross-sectional observational single-center study included 114 consecutively enrolled patients with alcohol-related cirrhosis (mean age 58.48 ± 9.09 years; 77.19% male) at the Gastroenterology/Internal Medicine I Department of the Emergency Clinical Hospital of Craiova between September 2024 and February 2025. Inflammatory biomarkers, including C-reactive protein, ferritin, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), were analyzed in relation to Child–Pugh and MELD scores. Correlation and regression analyses were performed to assess their associations with disease severity. Results: CRP, ferritin, NLR, and LMR showed significant correlations with both Child–Pugh and MELD scores, whereas PLR and SII were not significantly associated with disease severity. In multivariable analyses, ferritin remained significantly associated with both Child–Pugh and MELD severity, whereas LMR remained significantly associated only with Child–Pugh severity. Overall, correlations were numerically stronger for Child–Pugh with CRP and LMR, whereas ferritin and NLR showed a slightly stronger correlation with MELD. Conclusions: Several inflammatory biomarkers were associated with established severity scores in alcohol-related cirrhosis, with ferritin showing the most consistent association across both scoring systems. These findings support the relationship between systemic inflammation and disease severity in alcohol-related cirrhosis.

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Cite

BibTeXRIS
BibTeX
@article{vasile2026association,
  title = {{Association of Inflammatory Biomarkers with Child–Pugh and MELD Scores in Alcohol-Related Cirrhosis}},
  author = {Luciana-Florentina Vasile and Mihaela Ionescu and Victor-Mihai Sacerdotianu and Petrică Popa and Sergiu Marian Cazacu and Bogdan Silviu Ungureanu and Ioan-Alexandru Văcariu and Alexandru-Valentin Popescu and Carmen-Daniela Neagoe},
  journal = {Biomolecules},
  year = {2026},
  month = nov,
  doi = {10.3390/biom16111611},
  url = {https://www.mdpi.com/2218-273X/16/11/1611},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association of Inflammatory Biomarkers with Child–Pugh and MELD Scores in Alcohol-Related Cirrhosis
AU  - Luciana-Florentina Vasile
AU  - Mihaela Ionescu
AU  - Victor-Mihai Sacerdotianu
AU  - Petrică Popa
AU  - Sergiu Marian Cazacu
AU  - Bogdan Silviu Ungureanu
AU  - Ioan-Alexandru Văcariu
AU  - Alexandru-Valentin Popescu
AU  - Carmen-Daniela Neagoe
PY  - 2026
DA  - 2026/11/04
JO  - Biomolecules
DO  - 10.3390/biom16111611
UR  - https://www.mdpi.com/2218-273X/16/11/1611
AB  - Background: Cirrhosis is characterized by persistent systemic inflammation and immune dysregulation, both contributing to disease progression and poor clinical outcomes. Readily available inflammatory biomarkers have been proposed as complementary tools for disease severity assessment; however, data in alcohol-related cirrhosis remain limited. This study aimed to evaluate the association between inflammatory markers and established severity scores in patients with alcohol-related cirrhosis. Methods: This prospective cross-sectional observational single-center study included 114 consecutively enrolled patients with alcohol-related cirrhosis (mean age 58.48 ± 9.09 years; 77.19% male) at the Gastroenterology/Internal Medicine I Department of the Emergency Clinical Hospital of Craiova between September 2024 and February 2025. Inflammatory biomarkers, including C-reactive protein, ferritin, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII), were analyzed in relation to Child–Pugh and MELD scores. Correlation and regression analyses were performed to assess their associations with disease severity. Results: CRP, ferritin, NLR, and LMR showed significant correlations with both Child–Pugh and MELD scores, whereas PLR and SII were not significantly associated with disease severity. In multivariable analyses, ferritin remained significantly associated with both Child–Pugh and MELD severity, whereas LMR remained significantly associated only with Child–Pugh severity. Overall, correlations were numerically stronger for Child–Pugh with CRP and LMR, whereas ferritin and NLR showed a slightly stronger correlation with MELD. Conclusions: Several inflammatory biomarkers were associated with established severity scores in alcohol-related cirrhosis, with ferritin showing the most consistent association across both scoring systems. These findings support the relationship between systemic inflammation and disease severity in alcohol-related cirrhosis.
SN  - 2218-273X
ER  -