Dynamics of changes in the trace element balance of rat liver under subacute exposure to cadmium chloride combined with biometal succinates
- 1Dnipro State Medical University, Volodymyra Vernadskoho str., 9, Dnipro, 49044
Abstract
The study aimed to determine the dynamics of changes in the accumulation of cadmium and biogenic metals in the liver of experimental pregnant female rats under chronic isolated administration and when combined with biometal succinates. Based on the results of polyelement analysis, the degree of dyselementosis in the liver microelement composition and the bioprotective properties of zinc, iron, and copper succinates were evaluated. The effect of cadmium chloride on the accumulation levels of zinc, iron, and copper in the rat liver was assessed during their simultaneous entry into the body throughout pregnancy. An exceptionally high capacity for cadmium accumulation was established, with a critical excess over the control group by 67-fold on day 13 and by 87-fold at the end of the experiment. Iron, zinc, and copper succinates exhibit a pronounced protective effect, significantly reducing cadmium accumulation in the liver of pregnant rats on days 13 and 19 of the study. In terms of efficacy in limiting toxicant accumulation, the compounds form the following descending order: iron succinate > zinc succinate > copper succinate. Chronic cadmium intoxication was found to disrupt zinc metabolism in the liver of pregnant rats, abnormally increasing its level by 1.9-fold (day 13) and 1.4-fold (day 19) as a protective response for metallothionein biosynthesis. The administration of biogenic metal succinates effectively modulates this process; however, their normalizing effect depends on the gestational age. For the correction of zinc metabolism disorders, copper succinate is priority in the first half of pregnancy, while iron succinate is preferred in the second half. It was established that cadmium chloride intoxication profoundly disrupts iron metabolism and blocks its transport mechanisms, causing a rapid and significant (p<0.05) accumulation of iron in the liver parenchyma by more than 2-fold. This indicates a pronounced toxic effect of the xenobiotic on the iron-storing function of the liver at both gestational stages. The most pronounced protective effect was demonstrated by zinc succinate, which maintained the iron concentration at a level closest to the control values. This confirms the high efficiency of zinc succinate in supporting microelement homeostasis at both periods of the study. The effect of cadmium chloride on copper homeostasis disruption in the liver parenchyma of pregnant females was evaluated. It caused a rapid and significant increase in copper concentration throughout the entire observation period, indicating profound cadmium-induced alterations in the microelement balance and the retention of essential metals in the maternal depot.
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BibTeX
@article{shatorna2026dynamics,
title = {{Dynamics of changes in the trace element balance of rat liver under subacute exposure to cadmium chloride combined with biometal succinates}},
author = {V.F. Shatorna and S.V. Zakharov and I.M. Zakut},
journal = {Medičnì Perspektivi},
year = {2026},
month = sep,
doi = {10.26641/2307-0404.2026.3.376665},
url = {https://doi.org/10.26641/2307-0404.2026.3.376665},
note = {CC BY},
}
RIS
TY - JOUR
TI - Dynamics of changes in the trace element balance of rat liver under subacute exposure to cadmium chloride combined with biometal succinates
AU - V.F. Shatorna
AU - S.V. Zakharov
AU - I.M. Zakut
PY - 2026
DA - 2026/09/01
JO - Medičnì Perspektivi
DO - 10.26641/2307-0404.2026.3.376665
UR - https://doi.org/10.26641/2307-0404.2026.3.376665
AB - The study aimed to determine the dynamics of changes in the accumulation of cadmium and biogenic metals in the liver of experimental pregnant female rats under chronic isolated administration and when combined with biometal succinates. Based on the results of polyelement analysis, the degree of dyselementosis in the liver microelement composition and the bioprotective properties of zinc, iron, and copper succinates were evaluated. The effect of cadmium chloride on the accumulation levels of zinc, iron, and copper in the rat liver was assessed during their simultaneous entry into the body throughout pregnancy. An exceptionally high capacity for cadmium accumulation was established, with a critical excess over the control group by 67-fold on day 13 and by 87-fold at the end of the experiment. Iron, zinc, and copper succinates exhibit a pronounced protective effect, significantly reducing cadmium accumulation in the liver of pregnant rats on days 13 and 19 of the study. In terms of efficacy in limiting toxicant accumulation, the compounds form the following descending order: iron succinate > zinc succinate > copper succinate. Chronic cadmium intoxication was found to disrupt zinc metabolism in the liver of pregnant rats, abnormally increasing its level by 1.9-fold (day 13) and 1.4-fold (day 19) as a protective response for metallothionein biosynthesis. The administration of biogenic metal succinates effectively modulates this process; however, their normalizing effect depends on the gestational age. For the correction of zinc metabolism disorders, copper succinate is priority in the first half of pregnancy, while iron succinate is preferred in the second half. It was established that cadmium chloride intoxication profoundly disrupts iron metabolism and blocks its transport mechanisms, causing a rapid and significant (p<0.05) accumulation of iron in the liver parenchyma by more than 2-fold. This indicates a pronounced toxic effect of the xenobiotic on the iron-storing function of the liver at both gestational stages. The most pronounced protective effect was demonstrated by zinc succinate, which maintained the iron concentration at a level closest to the control values. This confirms the high efficiency of zinc succinate in supporting microelement homeostasis at both periods of the study. The effect of cadmium chloride on copper homeostasis disruption in the liver parenchyma of pregnant females was evaluated. It caused a rapid and significant increase in copper concentration throughout the entire observation period, indicating profound cadmium-induced alterations in the microelement balance and the retention of essential metals in the maternal depot.
SN - 2307-0404
SN - 2786-4804
ER -