Unifocal Frontal Bone Langerhans Cell Histiocytosis Presenting as Persistent Post-Traumatic Swelling in a Child with an Asthma Exacerbation: A Case Report.
- 1Faculty of Medical Sciences, Universidad de Especialidades Espíritu Santo, Samborondón, Ecuador.
- 2Medical Education and Research, Briones PulmoCare, Guayaquil, Ecuador.
Abstract
Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the clonal proliferation of Langerhans cells, and osseous involvement is the most frequent manifestation in pediatric patients. Although pulmonary involvement is recognized in LCH, respiratory presentations typically reflect direct pulmonary or airway disease rather than reversible obstructive symptoms. We report the case of a 4-year-old child with persistent, painful frontal swelling following minor trauma, which was initially presumed to be a post-traumatic hematoma. During the diagnostic course, the patient developed an asthma exacerbation that improved with bronchodilator and corticosteroid therapy. Imaging revealed a solitary osteolytic lesion of the frontal bone, and histopathological examination confirmed unifocal LCH. No clinical or chest radiographic evidence of pulmonary involvement was identified. This case underscored that persistent post-traumatic cranial swelling warrants imaging and histopathological evaluation, and highlights that the concurrent asthma exacerbation represents a temporal clinical overlap without proven causality.
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BibTeX
@article{brioneszamora2026unifocal,
title = {{Unifocal Frontal Bone Langerhans Cell Histiocytosis Presenting as Persistent Post-Traumatic Swelling in a Child with an Asthma Exacerbation: A Case Report.}},
author = {Killen H Briones-Zamora and Ana Polanco Montero and Jessica Monroy Castro and Ana Victoria Carrera-Cantos and Karelys Nicole Arteaga Ocaña and Anahí D Briones-Zamora and Killen H Briones-Claudett},
journal = {Iranian journal of medical sciences},
year = {2026},
month = oct,
doi = {10.30476/ijms.2026.110654.4637},
url = {https://europepmc.org/article/MED/42999547},
note = {CC BY-ND},
}
RIS
TY - JOUR
TI - Unifocal Frontal Bone Langerhans Cell Histiocytosis Presenting as Persistent Post-Traumatic Swelling in a Child with an Asthma Exacerbation: A Case Report.
AU - Killen H Briones-Zamora
AU - Ana Polanco Montero
AU - Jessica Monroy Castro
AU - Ana Victoria Carrera-Cantos
AU - Karelys Nicole Arteaga Ocaña
AU - Anahí D Briones-Zamora
AU - Killen H Briones-Claudett
PY - 2026
DA - 2026/10/01
JO - Iranian journal of medical sciences
DO - 10.30476/ijms.2026.110654.4637
UR - https://europepmc.org/article/MED/42999547
AB - Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the clonal proliferation of Langerhans cells, and osseous involvement is the most frequent manifestation in pediatric patients. Although pulmonary involvement is recognized in LCH, respiratory presentations typically reflect direct pulmonary or airway disease rather than reversible obstructive symptoms. We report the case of a 4-year-old child with persistent, painful frontal swelling following minor trauma, which was initially presumed to be a post-traumatic hematoma. During the diagnostic course, the patient developed an asthma exacerbation that improved with bronchodilator and corticosteroid therapy. Imaging revealed a solitary osteolytic lesion of the frontal bone, and histopathological examination confirmed unifocal LCH. No clinical or chest radiographic evidence of pulmonary involvement was identified. This case underscored that persistent post-traumatic cranial swelling warrants imaging and histopathological evaluation, and highlights that the concurrent asthma exacerbation represents a temporal clinical overlap without proven causality.
SN - 0253-0716
SN - 1735-3688
ER -