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Peer-reviewedCC BY 4.0Frontiers in Cardiovascular Medicine

Cardiovascular complications as a consequence of coronavirus infection in pregnant women managed in ambulatory settings

  • Ilia Davarashvili1,2
  • Ariel Israel3
  • Shlomo Vinker4
  • Hila Hochler5,6
6 affiliations
  1. 1Cardiology Department, Leumit Health Care
  2. 2O2 Health Promotion and Sports Medicine Department, The Howard and Mary Edith Cosell Association for Physical Education, The Safra Sports Center, Hebrew University
  3. 3Department of Epidemiology and Preventive Medicine, Gray Faculty of Medical & Health Sciences, Tel Aviv University
  4. 4Israel and the Department of Family Medicine Gray Faculty of Medical & Health Sciences, Leumit Health Care, Tel Aviv University
  5. 5Adelson School of Medicine, Ariel University
  6. 6Department of Obstetrics and Gynecology, Laniado Medical Center
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Abstract

Background: SARS-CoV-2 has been linked to cardiovascular complications in the general population. However, data regarding cardiovascular outcomes among pregnant women remain limited, particularly in community-based ambulatory populations, as most previous studies focused primarily on hospitalized or critically ill patients. In this retrospective population-based matched cohort study, we evaluated whether COVID-19 infection during pregnancy is associated with an increased incidence of cardiovascular complications among pregnant women managed predominantly in outpatient settings.

Methods: We conducted a retrospective population-based matched cohort study using electronic health record data from pregnant women between 2020 and 2025. Women with COVID-19 during pregnancy were matched 1:1 to women without documented COVID-19 during pregnancy according to demographic, obstetric, and clinical characteristics. The final analytical cohort included 4,068 women in each group. Cardiovascular outcomes during pregnancy and within a year since last menstrual period were assessed. Baseline demographic and obstetric characteristics were comparable between the COVID-19 and control groups. No significant differences were observed between the groups in the incidence of major cardiovascular complications, either when analyzed individually or as a composite endpoint (0.15% vs. 0.15%; OR 1.00, 95% CI 0.27–3.74). Specifically, there were no significant differences in the occurrence of atrial fibrillation/flutter, congestive heart failure, cardiomyopathy, myocarditis, pulmonary embolism, or deep venous thrombosis. In contrast, cough and backache were significantly more frequent among women with COVID-19 than among matched controls (6.88% vs. 4.87%; OR 1.45, 95% CI 1.19–1.75; 13.8% vs. 11.8%; OR 1.20, 95% CI 1.05–1.37; p = 0.007 respectively).

Conclusions: Our findings suggest that among pregnant women in ambulatory community settings, COVID-19 infection is not associated with an increased risk of major cardiovascular complications.

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Cite

BibTeXRIS
BibTeX
@article{davarashvili2026cardiovascular,
  title = {{Cardiovascular complications as a consequence of coronavirus infection in pregnant women managed in ambulatory settings}},
  author = {Ilia Davarashvili and Ariel Israel and Shlomo Vinker and Hila Hochler},
  journal = {Frontiers in Cardiovascular Medicine},
  year = {2026},
  month = oct,
  doi = {10.3389/fcvm.2026.1907396},
  url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1907396/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Cardiovascular complications as a consequence of coronavirus infection in pregnant women managed in ambulatory settings
AU  - Ilia Davarashvili
AU  - Ariel Israel
AU  - Shlomo Vinker
AU  - Hila Hochler
PY  - 2026
DA  - 2026/10/15
JO  - Frontiers in Cardiovascular Medicine
DO  - 10.3389/fcvm.2026.1907396
UR  - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1907396/full
AB  - Background: SARS-CoV-2 has been linked to cardiovascular complications in the general population. However, data regarding cardiovascular outcomes among pregnant women remain limited, particularly in community-based ambulatory populations, as most previous studies focused primarily on hospitalized or critically ill patients. In this retrospective population-based matched cohort study, we evaluated whether COVID-19 infection during pregnancy is associated with an increased incidence of cardiovascular complications among pregnant women managed predominantly in outpatient settings.  Methods: We conducted a retrospective population-based matched cohort study using electronic health record data from pregnant women between 2020 and 2025. Women with COVID-19 during pregnancy were matched 1:1 to women without documented COVID-19 during pregnancy according to demographic, obstetric, and clinical characteristics. The final analytical cohort included 4,068 women in each group. Cardiovascular outcomes during pregnancy and within a year since last menstrual period were assessed. Baseline demographic and obstetric characteristics were comparable between the COVID-19 and control groups. No significant differences were observed between the groups in the incidence of major cardiovascular complications, either when analyzed individually or as a composite endpoint (0.15% vs. 0.15%; OR 1.00, 95% CI 0.27–3.74). Specifically, there were no significant differences in the occurrence of atrial fibrillation/flutter, congestive heart failure, cardiomyopathy, myocarditis, pulmonary embolism, or deep venous thrombosis. In contrast, cough and backache were significantly more frequent among women with COVID-19 than among matched controls (6.88% vs. 4.87%; OR 1.45, 95% CI 1.19–1.75; 13.8% vs. 11.8%; OR 1.20, 95% CI 1.05–1.37; p = 0.007 respectively).  Conclusions: Our findings suggest that among pregnant women in ambulatory community settings, COVID-19 infection is not associated with an increased risk of major cardiovascular complications.
SN  - 2297-055X
ER  -