RNA-seq dataset of female germline stem cells treated with sodium lactate
- 1Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200240, China
- 2Emory University Rollins School of Public Health, GA, USA
- 3Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200240, China; Corresponding authors at: Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200240, China.
Abstract
Female germline stem cells(FGSC) are a type of adult stem cell found in the ovaries of animals which possess the ability to self-renew in vitro and differentiate into mature oocytes. Lactylation is a widespread post-translational modification of proteins that plays a crucial role in biological processes such as cell fate regulation and cell signaling, and has been shown to significantly influence processes such as immunity and development. However, the effects of altered lactylation on the development of female germline stem cells remain unclear. Therefore, we used sodium lactate treatment to modify the lactylation status of mouse-derived female germline stem Y cells(Supplementary Fig. 1) and employed RNA-seq technology to detect and analyze changes in lactylation-related genes and development-related genes. Through data cleaning of sequencing reads, genome alignment, and statistical testing, a total of 14,376 expressed genes were identified, of which 1,827 were significantly upregulated and 417 were significantly downregulated. We investigated the effects of altered lactic acid modification on the transcriptomic expression of female germline stem cells using GSEA enrichment analysis and mRNA alternative splicing analysis. This dataset will help us understand the effects of lactylation on processes such as proliferation and differentiation in female germline stem cells, providing a reference for research into the development of female germ cells.
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BibTeX
@article{guo2026rnaseq,
title = {{RNA-seq dataset of female germline stem cells treated with sodium lactate}},
author = {Yanyi Guo and Bo Xu and Jeffrey Jianan Gu and Yanlin Ma and Xiaopeng Hu and Ji Wu},
journal = {Data in Brief},
year = {2026},
month = aug,
doi = {10.1016/j.dib.2026.113348},
url = {https://doi.org/10.1016/j.dib.2026.113348},
note = {CC BY},
}
RIS
TY - JOUR
TI - RNA-seq dataset of female germline stem cells treated with sodium lactate
AU - Yanyi Guo
AU - Bo Xu
AU - Jeffrey Jianan Gu
AU - Yanlin Ma
AU - Xiaopeng Hu
AU - Ji Wu
PY - 2026
DA - 2026/08/01
JO - Data in Brief
DO - 10.1016/j.dib.2026.113348
UR - https://doi.org/10.1016/j.dib.2026.113348
AB - Female germline stem cells(FGSC) are a type of adult stem cell found in the ovaries of animals which possess the ability to self-renew in vitro and differentiate into mature oocytes. Lactylation is a widespread post-translational modification of proteins that plays a crucial role in biological processes such as cell fate regulation and cell signaling, and has been shown to significantly influence processes such as immunity and development. However, the effects of altered lactylation on the development of female germline stem cells remain unclear. Therefore, we used sodium lactate treatment to modify the lactylation status of mouse-derived female germline stem Y cells(Supplementary Fig. 1) and employed RNA-seq technology to detect and analyze changes in lactylation-related genes and development-related genes. Through data cleaning of sequencing reads, genome alignment, and statistical testing, a total of 14,376 expressed genes were identified, of which 1,827 were significantly upregulated and 417 were significantly downregulated. We investigated the effects of altered lactic acid modification on the transcriptomic expression of female germline stem cells using GSEA enrichment analysis and mRNA alternative splicing analysis. This dataset will help us understand the effects of lactylation on processes such as proliferation and differentiation in female germline stem cells, providing a reference for research into the development of female germ cells.
SN - 2352-3409
ER -