Clinical and Diagnostic Insights into Penile Angiolymphoid Hyperplasia with Eosinophilia Based on a Case and Analysis of Previous Literature.
- 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
- 2Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia.
Abstract
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular proliferation of unknown origin. It typically occurs in the head and neck region, but can occasionally manifest in unusual locations, such as the penis. Herein, we report a case of ALHE in a 46-year-old HIV-infected male presenting with multiple pruritic whitish nodules on the penile shaft with a size ranging from 0.5 × 0.5 × 0.1 cm to 1.1 × 0.6 × 0.2 cm, initially suspected to be nodular condyloma lata. However, negative serological syphilis test results excluded this initial diagnosis. Histopathological findings were consistent with ALHE, revealing plump endothelial cells and inflammatory infiltrates consisting of lymphocytes and eosinophils. The lesions did not fully resolve with topical corticosteroid therapy, thus necessitating surgical excision. As with ALHE at other sites, recurrence is to be anticipated. Although the pathogenesis remains unclear, an association between ALHE and HIV has been reported. ALHE presents both diagnostic and therapeutic challenges, particularly when it occurs in sensitive areas, such as the penis. While the penis is an atypical site for ALHE, awareness of this disease is important for dermatologists, and it should be included in the differential diagnosis of a penile nodule.
Related
- Apalutamide-induced drug reaction with eosinophilia and systemic symptoms and Stevens-Johnson syndrome overlap successfully treated with cyclosporine and benralizumab: A case report and literature review.
- The Clinical and Diagnostic Spectrum of Esophagitis Dissecans Superficialis: A Comprehensive Retrospective Case Series and Literature Review
- Inflammatory Papillary Hyperplasia: A Diagnostic Challenge to Oral Physicians
- Citation Impact and Public Attention Analysis of Benign Prostatic Hyperplasia Research in the Urological Literature
- Clinical and functional correlates of blood eosinophilia in pediatric asthma: A retrospective cohort study
BibTeX
@article{natasya2026clinical,
title = {{Clinical and Diagnostic Insights into Penile Angiolymphoid Hyperplasia with Eosinophilia Based on a Case and Analysis of Previous Literature.}},
author = {Rievanda Ayu Natasya and Retno Hesty Maharani and Eva Krishna Sutedja and Hermin Aminah Usman and Hanifah Nurul Huda and Pati Aji Achdiat},
journal = {Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)},
year = {2026},
month = oct,
doi = {10.1111/srt.70401},
url = {https://europepmc.org/article/MED/42920350},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Clinical and Diagnostic Insights into Penile Angiolymphoid Hyperplasia with Eosinophilia Based on a Case and Analysis of Previous Literature.
AU - Rievanda Ayu Natasya
AU - Retno Hesty Maharani
AU - Eva Krishna Sutedja
AU - Hermin Aminah Usman
AU - Hanifah Nurul Huda
AU - Pati Aji Achdiat
PY - 2026
DA - 2026/10/01
JO - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
DO - 10.1111/srt.70401
UR - https://europepmc.org/article/MED/42920350
AB - Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular proliferation of unknown origin. It typically occurs in the head and neck region, but can occasionally manifest in unusual locations, such as the penis. Herein, we report a case of ALHE in a 46-year-old HIV-infected male presenting with multiple pruritic whitish nodules on the penile shaft with a size ranging from 0.5 × 0.5 × 0.1 cm to 1.1 × 0.6 × 0.2 cm, initially suspected to be nodular condyloma lata. However, negative serological syphilis test results excluded this initial diagnosis. Histopathological findings were consistent with ALHE, revealing plump endothelial cells and inflammatory infiltrates consisting of lymphocytes and eosinophils. The lesions did not fully resolve with topical corticosteroid therapy, thus necessitating surgical excision. As with ALHE at other sites, recurrence is to be anticipated. Although the pathogenesis remains unclear, an association between ALHE and HIV has been reported. ALHE presents both diagnostic and therapeutic challenges, particularly when it occurs in sensitive areas, such as the penis. While the penis is an atypical site for ALHE, awareness of this disease is important for dermatologists, and it should be included in the differential diagnosis of a penile nodule.
SN - 0909-752X
SN - 1600-0846
ER -